Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones

Abstract : A series of 4′-alkyl-2′-hydroxyacetophenones were prepared by Suzuki cross-coupling reactions of 4′-bromo-2′-hydroxyacetophenone. In these reactions, alkyl(trifluoro)borates were found to be better reactants than alkylboronic acids. 4′-Alkyl-2′-hydroxyacetophenones are key intermediates for the further synthesis of -lipoflavonoids that are more readily incorporated into lipid bilayer membranes than flavonoids and should, therefore, have superior -biological effects through increased bioavailability.
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https://hal-unilim.archives-ouvertes.fr/hal-00938935
Contributeur : Vincent Sol <>
Soumis le : mercredi 29 janvier 2014 - 17:13:37
Dernière modification le : mardi 20 mars 2018 - 16:36:43

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Christelle Pouget, Patrick Trouillas, Rockhaya Gueye, Yves Champavier, A. Laurent, et al.. Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones. SYNLETT, Georg Thieme Verlag, 2014, pp.564-568. ⟨10.1055/s-0033-1340312⟩. ⟨hal-00938935⟩

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