Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones

Christelle Pouget; Patrick Trouillas; Rockhaya Gueye; Yves Champavier; A. Laurent; Jean-Luc Duroux; Vincent Sol; Catherine Fagnère

Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones

Christelle Pouget ^{1, *} Patrick Trouillas ¹ Rockhaya Gueye ¹ Yves Champavier ² A. Laurent ¹ Jean-Luc Duroux ¹ Vincent Sol ¹ Catherine Fagnère ¹

* Auteur correspondant

1 LCSN - Laboratoire de Chimie des Substances Naturelles

2 RMN - Service Commun de Résonance Magnétique Nucléaire

Abstract : A series of 4′-alkyl-2′-hydroxyacetophenones were prepared by Suzuki cross-coupling reactions of 4′-bromo-2′-hydroxyacetophenone. In these reactions, alkyl(trifluoro)borates were found to be better reactants than alkylboronic acids. 4′-Alkyl-2′-hydroxyacetophenones are key intermediates for the further synthesis of -lipoflavonoids that are more readily incorporated into lipid bilayer membranes than flavonoids and should, therefore, have superior -biological effects through increased bioavailability.

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00938935
Contributeur : Vincent Sol <>
Soumis le : mercredi 29 janvier 2014 - 17:13:37
Dernière modification le : mardi 20 mars 2018 - 16:36:43

Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones

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Exploring the Use of the Suzuki Coupling Reaction in the Synthesis of 4′-Alkyl-2′-hydroxyacetophenones

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