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Article dans une revue
De novo kidney graft tumors: results from a multicentric retrospective national study.
X. Tillou
A. Doerfler
S. Collon
F. Kleinclauss
J.-J. Patard
L. Badet
B. Barrou
M. Audet
H. Bensadoun
E. Berthoux
P. Bigot
J.-M. Boutin
Y. Bouzguenda
D. Chambade
R. Codas
J. Dantal
J. Deturmeny
M. Devonec
F. Dugardin
J.-M. Ferrière
1
A. Erauso
B. Feuillu
M. Gigante
L. Guy
G. Karam
2
T. Lebret
Y. Neuzillet
C. Legendre
3
T. Perez
4
Jean-Philippe Rerolle
5
L. Salomon
F. Sallusto
6
C. Sénéchal
N. Terrier
7
R. Thuret
G. Verhoest
J. Petit
Non Renseigné
J. Petit
Auteur
Non Renseigné
Auteur
1
Service d'urologie, andrologie et transplantation rénale (place Amélie-Raba-Léon, 33076 Bordeaux cedex - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
- Groupe hospitalier Pellegrin (France)
2
CE/SOE/LAU - Department of Civil Engineering [Lebanese American University] (School of Engineering, Jbail - Liban)
- SOE/LAU - School of Engineering [Lebanese American University] (Byblos Campus - Liban)
3
LDO - Domaines Océaniques (Technopôle Brest-Iroise, Place Copernic, 29280 Plouzané - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6538 (France)
- Institut d'écologie et environnement (France)
- Observatoire des Sciences de l'Univers (France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSU - CNRS - Institut national des sciences de l'Univers (INSU-CNRS 3 rue Michel-Ange, 75794 Paris Cedex 16 - France)
4
Department of Environmental Science [Philippines] (Loyola Height, Quezon City 1108, Philippines - Philippines)
- Ateneo de Manila University ( Katipunan Ave, Quezon City, 1108 Metro Manila, Philippines - Philippines)
5
PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation (Université de Limoges Faculté de médecine 2, rue du docteur Marcland 87025 LIMOGES CEDEX 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U850 (101, rue de Tolbiac, 75013 Paris - France)
- GEIST FR CNRS 3503 - Génomique, Environnement, Immunité, Santé, Thérapeutique : U850 (Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex - France)
- UNILIM - Université de Limoges : U850 (33 rue François Mitterrand BP23204 87032 Limoges - France)
- CHU Limoges (Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES - France)
6
Department of Multiorgan Transplantation (Faculty of Medicine Toulouse-Rangueil, Toulouse - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
Abstract : De novo tumors in renal allografts are rare and their prevalence is underestimated. We therefore analyzed renal cell carcinomas arising in renal allografts through a retrospective French renal transplant cohort. We performed a retrospective, multicentric survey by sending questionnaires to all French kidney transplantation centers. All graft tumors diagnosed after transplantation were considered as de novo tumors. Thirty-two centers participated in this study. Seventy-nine tumors were identified among 41 806 recipients (Incidence 0.19%). Patients were 54 men and 25 women with a mean age of 47 years old at the time of diagnosis. Mean tumor size was 27.8 mm. Seventy-four (93.6%), 53 (67%) and 44 tumors (55.6%) were organ confined (T1-2), low grade (G1-2) and papillary carcinomas, respectively. Four patients died of renal cell carcinomas (5%). The mean time lapse between transplantation and RCC diagnosis was 131.7 months. Thirty-five patients underwent conservative surgery by partial nephrectomy (n = 35, 44.3%) or radiofrequency (n = 5; 6.3%). The estimated 5 years cancer specific survival rate was 94%. Most of these tumors were small and incidental. Most tumors were papillary carcinoma, low stage and low grade carcinomas. Conservative treatment has been preferred each time it was feasible in order to avoid a return to dialysis.
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https://hal-unilim.archives-ouvertes.fr/hal-00942810
Contributeur : Pierre Marquet <>
Soumis le : jeudi 6 février 2014 - 15:07:47
Dernière modification le : mardi 2 février 2021 - 09:52:02
Contributeur : Pierre Marquet <>
Soumis le : jeudi 6 février 2014 - 15:07:47
Dernière modification le : mardi 2 février 2021 - 09:52:02
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Identifiants
- HAL Id : hal-00942810, version 1
- DOI : 10.1111/j.1600-6143.2012.04248.x
- PUBMED : 22959020
Citation
X. Tillou, A. Doerfler, S. Collon, F. Kleinclauss, J.-J. Patard, et al.. De novo kidney graft tumors: results from a multicentric retrospective national study.. American Journal of Transplantation, Wiley, 2012, 12 (12), pp.3308-15. ⟨10.1111/j.1600-6143.2012.04248.x⟩. ⟨hal-00942810⟩
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