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Article Dans Une Revue La Revue de Médecine Interne Année : 2014

[Pathophysiology of primary Sjögren's syndrome.]

C. Martel
Elisabeth Vidal
  • Fonction : Auteur
  • PersonId : 862209
Anne-Laure Fauchais
  • Fonction : Auteur
  • PersonId : 862208

Résumé

: Primary Sgögren's syndrome (SSP) is one of the most common connective tissue disorder with an estimated prevalence between 0.6 and 1.7% of the general population. Lymphocytic infiltration of salivary gland is easily accessible favoring the diagnosis, and clinical and fundamental research. However, while many advances have been obtained in the recent decades, the pathophysiology of SSP remains unclear combining environmental factors with genetic predisposition. A central role tends to be attributed to salivary gland epithelial cells, originally designated as "innocent bystanders" and to B cells through the intervention of survey factors like BAFF. New T cells subsets are also carefully studied, particularly natural T regulatory and Th17 cells. They could indeed represent new therapeutic targets.
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Dates et versions

hal-00945860 , version 1 (13-02-2014)

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Citer

C. Martel, Marie-Odile Jauberteau-Marchan, Elisabeth Vidal, Anne-Laure Fauchais. [Pathophysiology of primary Sjögren's syndrome.]. La Revue de Médecine Interne, 2014, epub ahead of print. ⟨10.1016/j.revmed.2013.12.011⟩. ⟨hal-00945860⟩
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