Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme.

Aurélie Delzor; Philippe Couratier; Farid Boumédiène; Marie Nicol; Michel Druet-Cabanac; François Paraf; Annick Méjean; Olivier Ploux; Jean-Philippe Leleu; Luc Brient; Marion Lengronne; Valérie Pichon; Audrey Combès; Saïda El Abdellaoui; Vincent Bonneterre; Emmeline Lagrange; Gérard Besson; Dominique Bicout; Jean Boutonnat; William Camu; Nicolas Pageot; Raul Juntas-Morales; Valérie Rigau; Estelle Masseret; Eric Abadie; Pierre-Marie Preux; Benoît Marin

doi:10.1136/bmjopen-2014-005528

Article dans une revue

Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme.

Aurélie Delzor ¹ Philippe Couratier ^{1, 2, *} Farid Boumédiène ¹ Marie Nicol ^{1, 2} Michel Druet-Cabanac ^{1, 3} François Paraf ^{2, 4} Annick Méjean ⁵ Olivier Ploux ⁵ Jean-Philippe Leleu ¹ Luc Brient ⁶ Marion Lengronne ⁶ Valérie Pichon ⁷ Audrey Combès ⁷ Saïda El Abdellaoui ⁷ Vincent Bonneterre ⁸ Emmeline Lagrange ⁹ Gérard Besson ⁹ Dominique Bicout ⁸ Jean Boutonnat ⁹ William Camu ^{10, 11} Nicolas Pageot ^{11, 10} Raul Juntas-Morales ^{11, 10} Valérie Rigau ^{11, 10} Estelle Masseret ¹² Eric Abadie ¹³ Pierre-Marie Preux ^{1, 14, 15} Benoît Marin ^{1, 14, 15}

* Auteur correspondant

1 NET - Neuroépidémiologie Tropicale

2 Service de Neurologie [CHU Limoges]

3 Service de Santé au Travail [CHU Limoges]

4 HCP - Homéostasie Cellulaire et Pathologies

5 LIED (UMR_8236) - Laboratoire Interdisciplinaire des Energies de Demain

6 ECOBIO - Ecosystèmes, biodiversité, évolution [Rennes]

7 LECA - Laboratoire Environnement et chimie analytique

8 TIMC - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525

9 CHU - Centre Hospitalier Universitaire [Grenoble]

10 INM - Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs

11 SLA CHRU Montpellier - Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]

12 ECOLAG - Ecosystèmes lagunaires : organisation biologique et fonctionnement

13 Laboratoire Environnement Resources-Languedoc Roussillon

14 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

15 Laboratoire de Biostatistique et d'Informatique Médicale

Abstract : INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disease. It occurs in two forms: (1) familial cases, for which several genes have been identified and (2) sporadic cases, for which various hypotheses have been formulated. Notably, the β-N-methylamino-L-alanine (L-BMAA) toxin has been postulated to be involved in the occurrence of sporadic ALS. The objective of the French BMAALS programme is to study the putative link between L-BMAA and ALS. METHODS AND ANALYSIS: The programme covers the period from 1 January 2003 to 31 December 2011. Using multiple sources of ascertainment, all the incident ALS cases diagnosed during this period in the area under study (10 counties spread over three French regions) were collected. First, the standardised incidence ratio will be calculated for each municipality under concern. Then, by applying spatial clustering techniques, overincidence and underincidence zones of ALS will be sought. A case-control study, in the subpopulation living in the identified areas, will gather information about patients' occupations, leisure activities and lifestyle habits in order to assess potential risk factors to which they are or have been exposed. Specimens of drinking water, food and biological material (brain tissue) will be examined to assess the presence of L-BMAA in the environment and tissues of ALS cases and controls. ETHICS AND DISSEMINATION: The study has been reviewed and approved by the French ethical committee of the CPP SOOM IV (Comité de Protection des Personnes Sud-Ouest & Outre-Mer IV). The results will be published in peer-reviewed journals and presented at national and international conferences.

Keywords : Amyotrophic lateral sclerosis β-N-methylamino-L-alanine L-BMAA toxin France

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-01073863
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 10 avril 2017 - 14:32:10
Dernière modification le : vendredi 15 mai 2020 - 12:22:04
Document(s) archivé(s) le : mardi 11 juillet 2017 - 13:47:21

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