Incidence of chronic myeloid leukemia and patient survival: Results of 5 french population-based cancer registries 1980-2009.

Amélie Penot; Pierre-Marie Preux; Sandra Le Guyader; Albert Collignon; Aurélie Herry; Vinciane Dufour; Alain Monnereau; Anne-Sophie Woronoff; Xavier Troussard; Elisabeth Pons; Dominique Bordessoule; Marc Maynadié

Incidence of chronic myeloid leukemia and patient survival: Results of 5 french population-based cancer registries 1980-2009.

Amélie Penot ^* Pierre-Marie Preux ^{1, 2, 3} Sandra Le Guyader Albert Collignon Aurélie Herry Vinciane Dufour Alain Monnereau Anne-Sophie Woronoff Xavier Troussard Elisabeth Pons Dominique Bordessoule ^{4, 5} Marc Maynadié

* Auteur correspondant

1 NET - Neuroépidémiologie Tropicale

2 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

3 Laboratoire de Biostatistique et d'Informatique Médicale

4 Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges]

5 CRIBL - Contrôle de la Réponse Immune B et des Lymphoproliférations

Abstract : ABSTRACT Treatment of chronic myeloid leukemia (CML) has seen several major advances over the past 30 years, notably with the introduction of interferon followed by Bcr-Abl tyrosine kinase inhibitors. We analyzed trends in the incidence of CML and patient survival in France. All cases recorded in five population-based registries between 1980 and 2009 were included. European (ESR) and world (WSR) standardized incidence rates as well as relative survival (RS) rates were estimated. We analyzed data for 781 patients (9863/3: 13.6%; 9875/3: 82.2%; 9876/3: 4.2%; mean age: 57.4 years). ESR was 1.02 [95%CI= 0.93-1.11] and WSR 0.81 [95%CI= 0.72-0.90]. The 5- RS rates among patients with Ph+_CML were 43.7% [30.9-61.9] when diagnosed in 1980-1986, 63.8% [56.9-71.5] in 1987-1999 and 88.7% [84.5-93.0] in 2000-2009. The eight-year RS rate of patients with Ph+_CML diagnosed in 2000-2009 was 83.3% [77.5-89.4]. Therapeutic innovations have thus led to a significant increase in long-term survival in the general CML patient population.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-01100563
Contributeur : Elisabeth Grelier <>
Soumis le : mardi 6 janvier 2015 - 16:07:46
Dernière modification le : lundi 24 septembre 2018 - 14:37:29

Incidence of chronic myeloid leukemia and patient survival: Results of 5 french population-based cancer registries 1980-2009.

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Incidence of chronic myeloid leukemia and patient survival: Results of 5 french population-based cancer registries 1980-2009.

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