Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe--the French register of ALS in Limousin (FRALim register).

Benoît Marin; Bello Hamidou; Philippe Couratier; Marie Nicol; Aurélie Delzor; Marie Raymondeau; Michel Druet-Cabanac; Géraldine Lautrette; Farid Boumédiène; Pierre-Marie Preux

Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe--the French register of ALS in Limousin (FRALim register).

Benoît Marin ^{1, 2, 3, *} Bello Hamidou ¹ Philippe Couratier ^{4, 1} Marie Nicol ^{1, 4} Aurélie Delzor ¹ Marie Raymondeau ¹ Michel Druet-Cabanac ^{1, 5} Géraldine Lautrette ⁴ Farid Boumédiène ^{1, 6} Pierre-Marie Preux ^{1, 2, 3}

* Auteur correspondant

1 NET - Neuroépidémiologie Tropicale

2 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

3 Laboratoire de Biostatistique et d'Informatique Médicale

4 Service de Neurologie [CHU Limoges]

5 Service de Santé au Travail [CHU Limoges]

6 GEOLAB - Laboratoire de Géographie Physique et Environnementale

Abstract : BACKGROUND AND PURPOSE: The main objective of establishing the French register of amyotrophic lateral sclerosis (ALS) in the Limousin region (FRALim), was to assess the incidence of ALS, in this ageing region of Europe, over a 12-year period (2000-2011). METHODS: Patients were included if they lived in Limousin at the time of diagnosis of ALS according to El Escorial revised criteria and were identified by at least one of the following sources: (i) the French national body coordinating ALS referral centres; (ii) public and private hospitals in the region; (iii) health insurance data related to long-term diseases. RESULTS: The FRALim register identified 279 incident cases (2000-2011). The crude and European population standardized incidences of ALS were as high as 3.19/100,000 person-years of follow-up (95% CI 2.81-3.56) and 2.58/100,000 person-years of follow-up (95% CI 2.27-2.89) respectively. Median age at onset was 70.8 years (interquartile range 63.1-77.1). The standardized sex incidence ratio (male/female) was 1.3 overall, but 1.1 under the age of 65 years, 1.7 between 65 and 75 years and 1.9 above 75 years. The exhaustiveness of the register has been estimated at 98.4% (95% CI 95.6-99.4) by capture-recapture analysis. CONCLUSION: It was possible for the first time in France to monitor accurately the incidence of ALS over a long time period. It appears to be in the upper range of data reported in western countries. Patterns displayed here might anticipate the epidemiology of ALS in ageing western countries.

Keywords : amyotrophic lateral sclerosis epidemiology France incidence population register

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-01101244
Contributeur : Elisabeth Grelier <>
Soumis le : jeudi 8 janvier 2015 - 11:12:54
Dernière modification le : vendredi 22 février 2019 - 01:33:06

Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe--the French register of ALS in Limousin (FRALim register).

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Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe--the French register of ALS in Limousin (FRALim register).

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