CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment

Mohamed Touati; Manuela Delage-Corre; Jacques Monteil; Julie Abraham; Stéphane Moreau; Liliane Remenieras; Marie-Pierre Gourin; Nataliya Dmytruk; Agnès Olivrie; Pascal Turlure; Stéphane Girault; François Labrousse; Pierre-Marie Preux; Arnaud Jaccard; Dominique Bordessoule

doi:10.3109/10428194.2014.917636

Article dans une revue

CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment

Mohamed Touati ^* Manuela Delage-Corre Jacques Monteil Julie Abraham Stéphane Moreau Liliane Remenieras Marie-Pierre Gourin Nataliya Dmytruk Agnès Olivrie ¹ Pascal Turlure ¹ Stéphane Girault ¹ François Labrousse ^{2, 3, 4} Pierre-Marie Preux ^{5, 6, 7} Arnaud Jaccard ^{1, 8} Dominique Bordessoule ^{1, 8}

* Auteur correspondant

1 Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges]

2 HCP - Homéostasie Cellulaire et Pathologies

3 Service d'Hématologie biologique [CHU Limoges]

4 UNILIM - Université de Limoges

5 NET - Neuroépidémiologie Tropicale

6 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

7 Laboratoire de Biostatistique et d'Informatique Médicale

8 CRIBL - Contrôle de la Réponse Immune B et des Lymphoproliférations

Abstract : inding new prognostic factors to identify patients with Hodgkin lymphoma (HL) at risk of treatment resistance or relapse remains challenging in daily practice. We evaluated the relationship between CD68 expression, interim positron emission tomography (iPET) results and outcome in 158 patients with HL diagnosed from February 1995 to July 2011. Immunohistochemistry (anti-CD68) gave two groups: low with ≤ 25% positive cells (121 patients) and high with > 25% (37 patients). Five-year overall survival was higher in the low group (88.4% vs. 63.2%, p = 0.0151), as was progression-free survival (74.5% vs. 40.7%, p = 0.0003). In 68 patients evaluable, iPET correlated with CD68: 13/52 patients (25%) in the low group had positive iPET as compared to 11/16 patients (68%) in the high group (p = 0.0016). This study confirms the prognostic value of CD68 in HL. We found a correlation between CD68 and iPET suggesting potential for a better stratification.

Keywords : Hodgkin lymphoma CD68 interim FDG-PET prognosis

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-01139063
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CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment

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CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment

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