Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.

Benoît Borel; Erwan Leclair; Delphine Thevenet; Laurent Beghin; Frédéric Gottrand; Claudine Fabre

Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.

Benoît Borel ¹ Erwan Leclair ² Delphine Thevenet ³ Laurent Beghin ⁴ Frédéric Gottrand ⁴ Claudine Fabre ⁵

1 HAVAE - Handicap, Activité, Vieillissement, Autonomie, Environnement

2 UDSL, EA 3608, Faculté des Sciences du Sport et de l'Education Physique

3 MMA

LBMS - Laboratoire brestois de mécanique et des systèmes

4 Inflammation: mécanismes et régulation et interactions avec la nutrition et les candidoses

5 CLLE-LTC - Cognition, Langues, Langage, Ergonomie

Abstract : To analyze breathing pattern and mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis (CF) children. Thirteen healthy children and 6 children with cystic fibrosis volunteered to perform an incremental test on a treadmill. Exercise tidal flow/volume loops were plotted every minute within a maximal flow/volume loop (MFVL). Expiratory flow limitation (expFL expressed in %Vt) was evaluated and end-expiratory and end-inspiratory lung volumes (EELV and EILV) were estimated from expiratory reserve volume relative to vital capacity (ERV/FVC) and from inspiratory reserve volume relative to vital capacity (IRV/FVC). During the incremental exercise, expFL was first observed at 40% of maximal aerobic speed in both groups. At maximal exercise, 46% of healthy children and 83% of CF children presented expFL, without significant effect of cystic fibrosis on the severity of expFL. According to the two-way ANOVA results, both groups adopted similar breathing pattern and breathing strategies as no significant effect of CF has been revealed. But, according to one-way ANOVA results, a significant increase of ERV/FVC associated with a significant decrease of IRV/FVC from resting value shave been observed in healthy children at maximal exercise, but not in CF children. The hypothesis of this study was based on the assumption that mild cystic fibrosis could induce more frequent and more severe mechanical ventilatory constraints due to pulmonary impairment and breathing pattern disturbances. But, this study did not succeed to highlight an effect of mild cystic fibrosis on the mechanical ventilatory constraints (expFL and dynamic hyperinflation) that occur during an incremental exercise. This absence of effect could be due to the absence of an impact of the disease on spirometric data, breathing pattern regulation during exercise and breathing strategy.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-01145758
Contributeur : Jean-Christophe Daviet <>
Soumis le : dimanche 26 avril 2015 - 11:59:28
Dernière modification le : jeudi 21 février 2019 - 11:02:54

Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.

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Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.

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