Undue regulatory control on phenobarbital-an important yet overlooked reason for the epilepsy treatment gap

Abstract : Epilepsy is a major chronic noncommunicable neurologic disorder. Although a simple, safe, efficacious, and low-cost treatment has been available for nearly 100 years, the treatment gap remains disturbingly high in many low- and middle-income countries (LMICs).[1] Treatment gap is generally defined as a “difference between the number of people with active epilepsy and the number being appropriately treated.” There are many reasons for this treatment gap; one important reason is an overly restrictive regulation on barbiturates such as phenobarbital (PB). These restrictive regulations deserve a wider and open discussion, even though epileptologists and others are intensely engaged on reducing the epilepsy treatment gap. With this article, we provide our viewpoint with an aim of raising an extremely important issue: undue regulatory restriction on phenobarbital, an essential lifesaving antiepileptic drug (AED).
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https://hal-unilim.archives-ouvertes.fr/hal-01204883
Contributeur : Elisabeth Grelier <>
Soumis le : jeudi 24 septembre 2015 - 16:27:27
Dernière modification le : vendredi 8 juin 2018 - 10:16:02

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Devender Bhalla, Hasan Aziz, Donna Bergen, Gretchen L. Birbeck, Arturo Carpio, et al.. Undue regulatory control on phenobarbital-an important yet overlooked reason for the epilepsy treatment gap. Epilepsia, Wiley, 2015, 56 (4), pp.659-662. ⟨10.1111/epi.12929⟩. ⟨hal-01204883⟩

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