Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.

Abstract : To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. Cross-sectional study. French community-dwelling people. Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function. Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.
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https://hal-unilim.archives-ouvertes.fr/hal-01216401
Contributeur : Jean-Christophe Daviet <>
Soumis le : vendredi 16 octobre 2015 - 11:13:25
Dernière modification le : vendredi 11 octobre 2019 - 20:23:02

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  • HAL Id : hal-01216401, version 1
  • PUBMED : 26200930

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Philipe de Souto Barreto, Sandrine Andrieu, Pierre Payoux, Laurent Demougeot, Yves Rolland, et al.. Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.. Journal of the American Geriatrics Society, Wiley, 2015, 63 (8), pp.1634-9. ⟨hal-01216401⟩

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