Stratification of ALS patients' survival: a population-based study.

Benoît Marin; Philippe Couratier; Simona Arcuti; Massimiliano Copetti; Andrea Fontana; Marie Nicol; Marie Raymondeau; Giancarlo Logroscino; Pierre-Marie Preux

Stratification of ALS patients' survival: a population-based study.

Benoît Marin ^{1, 2, 3} Philippe Couratier ^{3, 4} Simona Arcuti ⁵ Massimiliano Copetti ⁶ Andrea Fontana Marie Nicol ^{3, 4} Marie Raymondeau ^{7, 3} Giancarlo Logroscino ⁵ Pierre-Marie Preux ^{3, 1, 2}

1 Laboratoire de Biostatistique et d'Informatique Médicale

2 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

3 NET - Neuroépidémiologie Tropicale

4 Service de Neurologie [CHU Limoges]

5 Università degli studi di Bari

6 Statistic Unit

7 UFRCB - Unité Fonctionnelle de Recherche Clinique et de Biostatistique

Abstract : The natural history of amyotrophic lateral sclerosis (ALS) and patient risk stratification are areas of considerable research interest. We aimed (1) to describe the survival of a representative cohort of French ALS patients, and (2) to identify covariates associated with various patterns of survival using a risk classification analysis. ALS patients recruited in the FRALim register (2000-2013) were included. Time-to-death analyses were performed using Kaplan-Meier method and Cox model. A recursive partitioning and amalgamation (RECPAM) algorithm analysis identified subgroups of patients with different patterns of survival. Among 322 patients, median survival times were 26.2 and 15.6 months from time of onset and of diagnosis, respectively. Four groups of patients were identified, depending on their baseline characteristics and survival (1) ALSFRS-R slope >0.46/month and definite or probable ALS (median survival time (MST) 10.6 months); (2) ALSFRS-R slope >0.46/month and possible or probable laboratory-supported ALS (MST: 18.1 months); (3) ALSFRS-R slope ≤0.46/month and definite or probable ALS (MST: 22.5 months), and (4) ALSFRS-R slope ≤0.46/month and possible or probable laboratory-supported ALS (MST: 37.6 months). Median survival time is among the shortest ever reported by a worldwide population-based study. This is probably related to the age structure of the patients (the oldest identified to date), driven by the underlying population (30 % of subjects older than 60 years). Further research in the field of risk stratification could help physicians better anticipate prognosis of ALS patients, and help improve the design of randomized controlled trials.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-01224246
Contributeur : Elisabeth Grelier <>
Soumis le : mercredi 4 novembre 2015 - 14:00:41
Dernière modification le : mardi 12 février 2019 - 16:32:58

Stratification of ALS patients' survival: a population-based study.

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