Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

H Cheloufi (1) , B Belhani (1) , Tan-Sothea Ouk (2) , Rachida Zerrouki (2) , M. Berredjem (1) , N.-E. Aouf (1)

1 LAOC - Laboratory of Applied Organic Chemistry
2 LCSN - Laboratoire de Chimie des Substances Naturelles

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Mots clés: Antitumor; Cancer; Nitrogen mustard; Sulfonamides; Sulfonylcycloureas

Domaines: Chimie organique

H Cheloufi, B Belhani, Tan-Sothea Ouk, Rachida Zerrouki, M. Berredjem, et al.. Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard. Molecular Diversity, 2015, pp.1-7. ⟨10.1007/s11030-015-9647-6⟩. ⟨hal-01254441⟩