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Article Dans Une Revue Molecular Diversity Année : 2015

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

Résumé

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Domaines

Chimie organique
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Dates et versions

hal-01254441 , version 1 (12-01-2016)

Identifiants

Citer

H Cheloufi, B Belhani, Tan-Sothea Ouk, Rachida Zerrouki, M. Berredjem, et al.. Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard. Molecular Diversity, 2015, pp.1-7. ⟨10.1007/s11030-015-9647-6⟩. ⟨hal-01254441⟩
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