Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

Abstract : A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.
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Molecular Diversity, Springer Verlag, 2015, pp.1-7. 〈10.1007/s11030-015-9647-6〉
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Soumis le : mardi 12 janvier 2016 - 11:41:58
Dernière modification le : dimanche 8 avril 2018 - 13:38:01

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H Cheloufi, B Belhani, Tan-Sothea Ouk, Rachida Zerrouki, M. Berredjem, et al.. Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard. Molecular Diversity, Springer Verlag, 2015, pp.1-7. 〈10.1007/s11030-015-9647-6〉. 〈hal-01254441〉

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