Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

H Cheloufi; B Belhani; Tan-Sothea Ouk; Rachida Zerrouki; M. Berredjem; N.-E. Aouf

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

H Cheloufi ¹ B Belhani ¹ Tan-Sothea Ouk ² Rachida Zerrouki ² M. Berredjem ¹ N.-E. Aouf ¹

1 LAOC - Laboratory of Applied Organic Chemistry

2 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Keywords : Antitumor Cancer Nitrogen mustard Sulfonamides Sulfonylcycloureas

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

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https://hal-unilim.archives-ouvertes.fr/hal-01254441
Contributeur : Vincent Sol <>
Soumis le : mardi 12 janvier 2016 - 11:41:58
Dernière modification le : dimanche 8 avril 2018 - 13:38:01

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

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Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

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