Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Abstract : The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
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Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26, pp.941-945. 〈10.1016/j.bmcl.2015.12.060〉
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https://hal-unilim.archives-ouvertes.fr/hal-01257118
Contributeur : Vincent Sol <>
Soumis le : vendredi 15 janvier 2016 - 17:40:50
Dernière modification le : mardi 20 mars 2018 - 16:36:33

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Gautier Mark Arthur Ndong Ntoutoume, Robert Granet, Jean-Pierre Mbakidi, Frédérique Brégier, David Yannick Leger, et al.. Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26, pp.941-945. 〈10.1016/j.bmcl.2015.12.060〉. 〈hal-01257118〉

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