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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2015

Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membrane

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Résumé

Lipid peroxidation is a major deleterious effect caused by oxidative stress. It is involved in various diseases such as atherosclerosis, rheumatoid arthritis and neurodegenerative diseases. In order to inhibit lipid peroxidation, antioxidants must efficiently scavenge free radicals and penetrate inside biological membranes. Lipocarbazole has recently been shown to be a powerful antioxidant in solution. Here, we show its powerful capacity as lipid peroxidation inhibitor. Its mechanism of action is rationalized based on molecular dynamics simulations on a biomembrane model, quantum calculations and experimental evaluation. The role of the lipocarbazole side chain is particularly highlighted as a critical chemical feature responsible for its antioxidant activity.
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Dates et versions

hal-01257158 , version 1 (15-01-2016)

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Citer

Gabin Fabre, A. Hänchen, Claude-Alain Calliste, Karel Berka, S Banala, et al.. Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membrane . Bioorganic and Medicinal Chemistry, 2015, 23 (15), pp.4866-4870. ⟨10.1016/j.bmc.2015.05.031⟩. ⟨hal-01257158⟩
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