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Article dans une revue
Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membrane
Abstract : Lipid peroxidation is a major deleterious effect caused by oxidative stress. It is involved in various diseases such as atherosclerosis, rheumatoid arthritis and neurodegenerative diseases. In order to inhibit lipid peroxidation, antioxidants must efficiently scavenge free radicals and penetrate inside biological membranes. Lipocarbazole has recently been shown to be a powerful antioxidant in solution. Here, we show its powerful capacity as lipid peroxidation inhibitor. Its mechanism of action is rationalized based on molecular dynamics simulations on a biomembrane model, quantum calculations and experimental evaluation. The role of the lipocarbazole side chain is particularly highlighted as a critical chemical feature responsible for its antioxidant activity.
https://hal-unilim.archives-ouvertes.fr/hal-01257158
Contributeur : Vincent Sol Connectez-vous pour contacter le contributeur
Soumis le : vendredi 15 janvier 2016 - 18:13:17
Dernière modification le : dimanche 26 juin 2022 - 13:23:17
Contributeur : Vincent Sol Connectez-vous pour contacter le contributeur
Soumis le : vendredi 15 janvier 2016 - 18:13:17
Dernière modification le : dimanche 26 juin 2022 - 13:23:17
