Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes

Gabin Fabre (1, 2) , Imene Bayach (1) , Karel Berka (2) , Markéta Paloncýová (2) , M. Starok (3) , C. Rossi (3) , Jean-Luc Duroux (1) , Michal Otyepka (2) , Patrick Trouillas (2, 4)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 Department of Physical Chemistry
3 GEC - Génie Enzymatique et Cellulaire
4 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation

Vitamins E, C and polyphenols (flavonoids and non-flavonoids) are major natural antioxidants capable of preventing damage generated by oxidative stress. Here we show the capacity of these antioxidants to form non-covalent association within lipid bilayers close to the membrane/cytosol interface. Antioxidant regeneration is significantly enhanced in these complexes.

Mots clés: alpha tocopherol; antioxidant; ascorbic acid; flavonoid; quercetin; controlled study; cytosol; drug potentiation; enthalpy; lipid bilayer; lipophilicity; membrane; oxidative stress; simulation

Domaines: Chimie; Chimie organique; Chimie; Chimie; Chimie théorique et/ou physique

Gabin Fabre, Imene Bayach, Karel Berka, Markéta Paloncýová, M. Starok, et al.. Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes. Chemical Communications, 2015, 51 (36), pp.7713-7716. ⟨10.1039/c5cc00636h⟩. ⟨hal-01257166⟩