Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes

Gabin Fabre; Imene Bayach; Karel Berka; Markéta Paloncýová; M. Starok; C. Rossi; Jean-Luc Duroux; Michal Otyepka; Patrick Trouillas

Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes

Gabin Fabre ^{1, 2} Imene Bayach ¹ Karel Berka ² Markéta Paloncýová ² M. Starok ³ C. Rossi ³ Jean-Luc Duroux ¹ Michal Otyepka ² Patrick Trouillas ^{2, 4}

1 LCSN - Laboratoire de Chimie des Substances Naturelles

2 Department of Physical Chemistry

3 GEC - Génie Enzymatique et Cellulaire

4 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation

Abstract : Vitamins E, C and polyphenols (flavonoids and non-flavonoids) are major natural antioxidants capable of preventing damage generated by oxidative stress. Here we show the capacity of these antioxidants to form non-covalent association within lipid bilayers close to the membrane/cytosol interface. Antioxidant regeneration is significantly enhanced in these complexes.

Keywords : alpha tocopherol antioxidant ascorbic acid flavonoid quercetin controlled study cytosol drug potentiation enthalpy lipid bilayer lipophilicity membrane oxidative stress simulation

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

Chimie

Chimie / Chimie théorique et/ou physique

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https://hal-unilim.archives-ouvertes.fr/hal-01257166
Contributeur : Vincent Sol <>
Soumis le : vendredi 15 janvier 2016 - 18:29:14
Dernière modification le : vendredi 21 décembre 2018 - 10:13:49

Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes

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Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes

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