The photodynamic therapy: state of the art and perspectives

Céline Frochot (1, 2) , Muriel Barberi-Heyob (1, 3) , Mireille Blanchard-Desce (1, 4) , Lina Bolotine (1, 3) , Stéphanie Bonneau (1, 5) , Chiara Mauriello-Jimenez (6, 1) , Jean-Olivier Durand (1, 6) , Henri-Pierre Lassalle (1, 3) , Gilles Lemercier (1, 7) , Serge Mordon (1, 8) , Philippe Maillard (1, 9) , Vincent Sol (1, 10) , Christine Vever-Bizet (1, 5) , Patricia Vicendo (11, 1)

1 PHOTOMED - Médicaments Photoactivables - Photochimiothérapie
2 LRGP - Laboratoire Réactions et Génie des Procédés
3 CRAN - Centre de Recherche en Automatique de Nancy
4 ISM - Institut des Sciences Moléculaires
5 LJP - Laboratoire Jean Perrin
6 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
7 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
8 Thiais - Therapies Interventionnelles Assistees Par l'Image et la Simulation - U 703
9 Institut Curie [Paris]
10 LCSN - Laboratoire de Chimie des Substances Naturelles
11 IMRCP - Interactions moléculaires et réactivité chimique et photochimique

Photodynamic therapy (PDT) is a method of medical treatment using the concomitant action of a photoactivatable molecule called the photosensitizer (PS), light, and oxygen naturally present in the biological medium. After light excitation of the photosensitizer, an energy transfer to oxygen allows to generate the formation of reactive oxygen species, especially singlet oxygen reactive leading to cell death. This technique proves to be very efficient for certain types of cancer (especially in dermatology) and is promising in other pathologies (prostate, brain). This article briefly describes the principle of PDT and then analyzes the latest advances in PDT in terms of clinical applications (actinic keratoses, prostate, brain cancer, retinoblastoma) and the use of PDT for antibacterial applications. Finally, the prospects of this technique with among others the development of new vesicles or the use of X-rays as a source of energy to overcome the problems of light penetration in tissues are presented.

Mots clés: Photodynamic therapy; photosensitizer; cancer.

Domaines: Chimie; Chimie organique

Céline Frochot, Muriel Barberi-Heyob, Mireille Blanchard-Desce, Lina Bolotine, Stéphanie Bonneau, et al.. The photodynamic therapy: state of the art and perspectives. L'Actualité Chimique, 2015, juin juilllet 2015 (397-398), pp.46-50. ⟨hal-01257199⟩