Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s.

Patrick Akono Ntonga; Nicolas Baldovini; Elisabeth Mouray; Lengo Mambu; Philippe Belong; Philippe Grellier

doi:10.1051/parasite/2014033

Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s.

Patrick Akono Ntonga ^{1, *} Nicolas Baldovini ² Elisabeth Mouray ³ Lengo Mambu ⁴ Philippe Belong ⁵ Philippe Grellier ³

* Auteur correspondant

1 Laboratory of Animal Biology, Department of Animal Biology, Faculty of Science

2 ICN - Institut de Chimie de Nice

3 MCAM - Molécules de Communication et Adaptation des Micro-Organismes

4 LCSN - Laboratoire de Chimie des Substances Naturelles

5 Higher Teacher Training College,

Abstract : The biological activities of essential oils from three plants grown in Cameroon: Ocimum basilicum, Ocimum canum, and Cymbopogon citratus were tested against Plasmodium falciparum and mature-stage larvae of Anopheles funestus. Gas chromatography and gas chromatography - mass spectrometry analyses showed that the main compounds are geranial, 1,8-cineole and linalool in C. citratus, O. canum and O. basilicum, respectively. Larvicidal tests carried out according to the protocol recommended by the World Health Organization showed that the essential oil of leaves of C. citratus is the most active against larvae of An. funestus (LC50 values = 35.5 ppm and 34.6 ppm, respectively, for larval stages III and IV after 6 h of exposure). Besides, the in vitro anti-plasmodial activity evaluated by the radioisotopic method showed that the C. citratus oil is the most active against P. falciparum, with an IC 50 value of 4.2 ± 0.5 μg/mL compared with O. canum (20.6 ± 3.4 μg/mL) and O. basilicum (21 ± 4.6 μg/mL). These essential oils can be recommended for the development of natural biocides for fighting the larvae of malaria vectors and for the isolation of natural products with anti-malarial activity.

Keywords : Anopheles funestus s.s. Anti-malarial drugs Biocides Essential oils Plasmodium falciparum

Type de document :

Article dans une revue

Parasite, EDP Sciences, 2014, 21 (33), 〈10.1051/parasite/2014033〉

Domaine :

Chimie / Chimie thérapeutique

Chimie / Chimie analytique

Sciences du Vivant [q-bio] / Microbiologie et Parasitologie

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https://hal-unilim.archives-ouvertes.fr/hal-01257600
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Dernière modification le : vendredi 23 novembre 2018 - 15:16:02

Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s.

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Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s.

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