Multilocus Variable-Number Tandem-Repeat Analysis-Confirmed Emergence of a Macrolide Resistance-Associated Mutation in Mycoplasma pneumoniae during Macrolide Therapy for Interstitial Pneumonia in an Immunocompromised Child

Sébastien Hantz (1, 2) , Fabien Garnier (2, 1) , Olivia Peuchant (3, 4) , Céline Menetrey (5, 6) , Alain Charron (3) , Marie-Cécile Ploy (2, 1) , Cécile Bebear (4, 7) , Sabine Pereyre (3, 4)

1 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
2 Service de Bactériologie, Virologie, Hygiène [CHU Limoges]
3 Laboratoire de Bactériologie
4 Laboratoire de Bactériologie
5 Service de Pédiatrie médicale [CHU Limoges]
6 CIC1435 - Centre d'Investigation Clinique de Limoges
7 Service de Bactériologie

A child with Job's syndrome was treated for pneumonia due to Mycoplasma pneumoniae. A mixed population of wild-type bacteria and an A2059G mutant was detected during josamycin treatment failure. The same multilocus variable-number tandem-repeat analysis (MLVA) type (MLVA type I) was isolated before and after treatment failure. The child recovered after ciprofloxacin treatment.

Mots clés: MLVA; Mycoplasma pneumoniae infection; pneumonia

Domaines: Bactériologie; Maladies infectieuses

Sébastien Hantz, Fabien Garnier, Olivia Peuchant, Céline Menetrey, Alain Charron, et al.. Multilocus Variable-Number Tandem-Repeat Analysis-Confirmed Emergence of a Macrolide Resistance-Associated Mutation in Mycoplasma pneumoniae during Macrolide Therapy for Interstitial Pneumonia in an Immunocompromised Child. Journal of Clinical Microbiology, 2012, 50 (10), pp.3402-3405. ⟨10.1128/JCM.01248-12⟩. ⟨hal-01500787⟩