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Hypermetabolism is a deleterious prognostic factor in patients with Amyotrophic lateral sclerosis.

Abstract : Rationale: Hypermetabolism, defined as an excessive level of resting energy expenditure (REE) has been reported in 50 –60% of patients with amyotrophic lateral sclerosis (ALS). The aim of this study was to investigate a large cohort of ALS patients in order to determine their nutritional, neurological and respiratory parameters and their survival according to the metabolic level. Methods: Nutritional, neurological and respiratory assessments were prospectively recorded. Nutritional evaluationincluded body mass index, REE measured by indirect calorimetry (hypermetabolism if REE variation [ΔREE] >10%) and fat mass (FM) using impedancemetry. Neurological evaluation included ALS phenotype at time of diagnosis, site at onset, ALSFRS-R score. Respiratory evaluation included vital capacity and SNIFF test. Survival analysis used the Kaplan-Meier method and the multivariate Cox model. Results: 315 patients were analysed. Median age at diagnosis was 65.9 years. 55.2% of patients were hypermetabolic. According to the metabolic level (Δ REE < 10%, 10– 20% and >20%), patients with a Δ REE >20% initially had a lower FM, 29.7% vs. 32.1% in those ≤ 10% (p = 0.0054). SNIFF test tended to be lower in ALS patients with Δ REE >20% (p = 0.07). During follow-up, nutritional status did not differ between the three groups, The median slope of ALSFRS-R tended to evolve more severely in patients with Δ REE >20%, −1.4 points/month vs. − 1.0 points/month in those ≤ 10% (p = 0.07). Overall median survival since diagnosis was 18.4 months. Δ REE >20% tended to increase the risk of dying compared to ≤ 10% (HR = 1.33, p = 0.055). In multivariate analysis, an increased REE/FM ratio was independently associated with death (HR = 1.005, p = 0.001). Conclusion: Hypermetabolism is present in more than half of ALS patients. It modifies the body composition at diagnosis, and patients with hypermetabolism >20% have a worse prognosis.
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Contributeur : Elisabeth Grelier Connectez-vous pour contacter le contributeur
Soumis le : mercredi 11 octobre 2017 - 12:02:52
Dernière modification le : samedi 26 mars 2022 - 04:23:55


  • HAL Id : hal-01614706, version 1



Pierre Jésus, Philippe Fayemendy, Marie Nicol, Géraldine Lautrette, Huguette Sourisseau, et al.. Hypermetabolism is a deleterious prognostic factor in patients with Amyotrophic lateral sclerosis.. 39th Espen Congress, Sep 2017, La Hague, Netherlands. 36 (Supplément 1), pp.S34-S35, 2017, Clinical Nutrition. ⟨hal-01614706⟩



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