Ankle–Brachial Index: An Ubiquitous Marker of Cognitive Impairment—The EPIDEMCA Study

Abstract : Epidemiological research on the implication of atherosclerosis in the development of cognitive impairment is lacking in low- and middle-income countries, where two-thirds of the individuals affected by dementia live. Individuals aged ≥65 years living in urban and rural areas of 2 countries in Central Africa were invited. Demographic, clinical, and biological data were collected, and the ankle-brachial index (ABI) was measured. Cognitive impairment was defined according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria. Among 1662 participants (age 72.9 years, 59.3% females), the prevalence of cognitive impairment was 13.6%, which is higher in individuals with ABI ≤ 0.90 and ABI ≥ 1.40 than those with 0.90 < ABI < 1.40 (20.1% and 17% vs 12%, P = .0024). Cognitive impairment was significantly associated with the factors such as age (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.07-1.12, P < .0001), female gender (OR: 2.36, 95% CI: 1.59-3.49, P < .0001), smoking (OR: 1.54, 95% CI: 1.06-2.23, P = .0026), and low ABI (≤0.90; OR: 1.52, 95% CI: 1.03-2.25, P = .0359). The ABI, a ubiquitous marker of atherosclerosis, provides independent and incremental information on susceptibility to present with cognitive disorders.
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Angiology, SAGE Publications, 2017, 〈10.1177/0003319717736608〉
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https://hal-unilim.archives-ouvertes.fr/hal-01635516
Contributeur : Elisabeth Grelier <>
Soumis le : mercredi 15 novembre 2017 - 11:49:45
Dernière modification le : jeudi 14 juin 2018 - 09:24:01

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Iléana Desormais, Victor Aboyans, Maëlenn Guerchet, Bébène Ndamba-Bandzouzi, Pascal M'Belesso, et al.. Ankle–Brachial Index: An Ubiquitous Marker of Cognitive Impairment—The EPIDEMCA Study. Angiology, SAGE Publications, 2017, 〈10.1177/0003319717736608〉. 〈hal-01635516〉

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