Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus.

Pascal Trempat (1) , Julie Tabiasco (1) , Pascale Andre (2) , Nathalie Faumont (1) , Fabienne Meggetto (1) , Georges Delsol (3, 1) , Randy Gascoyne (4) , Jean-Jacques Fournié (1) , Eric Vivier (5) , Pierre Brousset (1)

1 INSERM U563 - CNRS UMR1037 - Centre de Physiopathologie de Toulouse-Purpan
2 Innate Pharma
3 CPTP - Centre de Physiopathologie Toulouse Purpan
4 British Columbia Cancer Agency, Vancouver,
5 CIML - Centre d'Immunologie de Marseille - Luminy

We examined lymph nodes and tonsils from patients with infectious mononucleosis by combined detection of EBV-encoded RNA and a specific marker of natural killer (NK) cells, PEN5. A small number of Epstein-Barr virus (EBV) latently infected nonneoplastic NK cells were detected. Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection.

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie moléculaire; Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Sciences du Vivant [q-bio]; Biologie cellulaire; Organisation et fonctions cellulaires [q-bio.SC]; Sciences du Vivant [q-bio]; Biologie cellulaire; Interactions cellulaires [q-bio.CB]; Sciences du Vivant [q-bio]; Cancer; Sciences du Vivant [q-bio]; Immunologie; Immunité adaptative; Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Hématologie

Pascal Trempat, Julie Tabiasco, Pascale Andre, Nathalie Faumont, Fabienne Meggetto, et al.. Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus.. Journal of Virology, 2002, pp.11139-11142. ⟨10.1128/JVI.76.21.11139-11142.2002⟩. ⟨hal-01759549⟩