Y. Yu, F. Su, B. Callaghan, S. Goutman, S. Batterman et al., Environmental Risk Factors and Amyotrophic Lateral Sclerosis (ALS): A Case-Control Study of ALS in Michigan, PLoS ONE, vol.162, issue.6, p.4076303, 2014.
DOI : 10.1371/journal.pone.0101186.s003

M. Liu, L. Cui, D. Fan, and A. Chinese, Age at onset of amyotrophic lateral sclerosis in China, Acta Neurologica Scandinavica, vol.127, issue.1, pp.163-170, 2014.
DOI : 10.1111/j.1600-0404.2012.01705.x

M. Sabatelli, A. Conte, and M. Zollino, Clinical and genetic heterogeneity of amyotrophic lateral sclerosis. Clinical genetics, pp.408-424, 2013.

P. Dreyer, C. Lorenzen, L. Schou, and M. Felding, Survival in ALS with home mechanical ventilation noninvasively and invasively: a 15-year cohort study in west Denmark Amyotrophic lateral sclerosis & frontotemporal degeneration, pp.62-69, 2014.

R. Spataro, L. Ficano, F. Piccoli, L. Bella, and V. , Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: Effect on survival, Journal of the Neurological Sciences, vol.304, issue.1-2, pp.44-52, 2011.
DOI : 10.1016/j.jns.2011.02.016

M. Gladman, C. Dharamshi, and L. Zinman, Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses Amyotrophic lateral sclerosis & frontotemporal degeneration, pp.5-6, 2014.

G. Logroscino, B. Traynor, O. Hardiman, A. Chio, D. Mitchell et al., Incidence of amyotrophic lateral sclerosis in Europe, Journal of Neurology, Neurosurgery & Psychiatry, vol.81, issue.4, pp.385-90, 2009.
DOI : 10.1136/jnnp.2009.183525

G. Logroscino, B. Traynor, O. Hardiman, A. Chio, P. Couratier et al., Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.1, pp.6-11, 2008.
DOI : 10.1136/jnnp.2006.104828
URL : https://hal.archives-ouvertes.fr/hal-00337671

K. Rothman, S. Greenland, and T. Lash, Modern epidemiology, 2008.

B. Traynor, M. Codd, B. Corr, C. Forde, E. Frost et al., Incidence and prevalence of ALS in Ireland: a population-based study, Neurology, vol.5220, issue.302, pp.504-513, 1995.

P. Piemonte and . Valle-d, Aosta Register for Amyotrophic Lateral Sclerosis Incidence of ALS in Italy: evidence for a uniform frequency in Western countries, Neurology, vol.56, issue.2, pp.239-283, 2001.

E. Beghi, A. Millul, A. Micheli, E. Vitelli, and G. Logroscino, Incidence of ALS in Lombardy, Italy, Neurology, vol.68, issue.2, pp.141-146, 2007.
DOI : 10.1212/01.wnl.0000250339.14392.bb

G. Logroscino, E. Beghi, S. Zoccolella, R. Palagano, A. Fraddosio et al., Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study, Journal of Neurology, Neurosurgery & Psychiatry, vol.76, issue.8, pp.1094-1102, 2005.
DOI : 10.1136/jnnp.2004.039180

B. Marin, B. Hamidou, P. Couratier, M. Nicol, A. Delzor et al., Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe - the French register of ALS in Limousin (FRALim register), European Journal of Neurology, vol.15, issue.10, pp.1292-300, 2014.
DOI : 10.3109/21678421.2013.837933
URL : https://hal.archives-ouvertes.fr/hal-01101244

C. Donaghy, C. J. Patterson, C. Kee, F. Hardiman, O. Patterson et al., The epidemiology of motor neuron disease in Northern Ireland using capture-recapture methodology Amyotrophic lateral sclerosis: official publication of the World Federation of, Neurology Research Group on Motor Neuron Diseases, vol.11, issue.4, pp.374-382, 2010.

J. Mandrioli, S. Biguzzi, C. Guidi, E. Venturini, E. Sette et al., Epidemiology of amyotrophic lateral sclerosis in Emilia Romagna Region (Italy): A population based study Amyotrophic lateral sclerosis & frontotemporal degeneration, pp.3-4262, 2014.

M. Bandettini-di-poggio, M. Sormani, R. Truffelli, P. Mandich, P. Origone et al., Clinical epidemiology of ALS in Liguria, Italy Amyotrophic lateral sclerosis & frontotemporal degeneration, Epub, vol.1410, issue.1, pp.52-59, 2012.

J. Pradas, T. Puig, R. Rojas-garcia, M. Viguera, I. Gich et al., Amyotrophic lateral sclerosis in Catalonia: a population based study Amyotrophic lateral sclerosis & frontotemporal degeneration, pp.278-83, 2013.

B. Brooks, El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors, Journal of the neurological sciences, vol.124, 1994.

B. Brooks, R. Miller, M. Swash, and T. Munsat, El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, vol.1, issue.5, pp.293-302, 2000.
DOI : 10.1080/146608200300079536

B. Traynor, A. M. Corr, B. Frost, E. Hardiman, and O. , Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, J Neurol Neurosurg Psychiatry . Epub, vol.7423, issue.9, pp.1258-61, 1996.

A. Chio, E. Bottacchi, C. Buffa, R. Mutani, and G. Mora, Positive effects of tertiary centres for amyotrophic lateral sclerosis on outcome and use of hospital facilities, Journal of Neurology, Neurosurgery & Psychiatry, vol.77, issue.8, pp.948-50, 2006.
DOI : 10.1136/jnnp.2005.083402

E. Von-elm, D. Altman, M. Egger, S. Pocock, P. Gotzsche et al., The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement, Epidemiology, vol.18, issue.6, pp.1453-1460, 2007.
DOI : 10.1097/EDE.0b013e3181577654

K. Ahmeti, S. Ajroud-driss, A. Chalabi, P. Andersen, J. Armstrong et al., Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34, Neurobiol Aging, vol.1, issue.341, pp.357-364, 2013.

R. Forbes, S. Colville, and R. Swingler, The epidemiology of amyotrophic lateral sclerosis (ALS/MND) in people aged 80 or over, Age and Ageing, vol.33, issue.2, pp.131-135, 2004.
DOI : 10.1093/ageing/afh013

A. Chio, G. Logroscino, O. Hardiman, R. Swingler, D. Mitchell et al., Prognostic factors in ALS: A critical review Amyotrophic lateral sclerosis: official publication of the World Federation of, Neurology Research Group on Motor Neuron Diseases. Epub, vol.1020, issue.11, pp.5-6310, 2009.

M. Dandaba, P. Couratier, A. Labrunie, M. Nicol, B. Hamidou et al., Characteristics and Prognosis of Oldest Old Subjects with Amyotrophic Lateral Sclerosis, Neuroepidemiology, vol.49, issue.1-2, pp.64-73, 2017.
DOI : 10.1016/S0733-8619(05)70049-9
URL : https://hal.archives-ouvertes.fr/hal-01586219

S. Byrne, C. Walsh, C. Lynch, P. Bede, M. Elamin et al., Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis, Journal of Neurology, Neurosurgery & Psychiatry, vol.82, issue.6, pp.623-630, 2011.
DOI : 10.1136/jnnp.2010.224501
URL : https://hal.archives-ouvertes.fr/hal-00591173

J. Rooney, S. Byrne, M. Heverin, B. Corr, M. Elamin et al., Survival Analysis of Irish Amyotrophic Lateral Sclerosis Patients Diagnosed from, PLoS ONE, vol.8, issue.9, 1995.

L. Haverkamp, V. Appel, and S. Appel, Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction, Brain, vol.118, issue.3, pp.707-1901, 1995.
DOI : 10.1093/brain/118.3.707

L. Kurland and D. Mulder, Epidemiologic Investigations of Amyotrophic Lateral Sclerosis: 2. Familial Aggregations Indicative of Dominant Inheritance Part II., Neurology, vol.5, issue.4, pp.249-68, 1955.
DOI : 10.1212/WNL.5.4.249

S. Byrne, M. Heverin, M. Elamin, P. Bede, C. Lynch et al., Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: A population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis, Annals of Neurology, vol.197, issue.suppl, pp.699-708, 2013.
DOI : 10.1192/bjp.bp.109.068981

A. Renton, A. Chio, and B. Traynor, State of play in amyotrophic lateral sclerosis genetics, Nature Neuroscience, vol.67, issue.1, pp.17-23, 2013.
DOI : 10.1002/ana.22611

M. Strong, A. Hudson, and W. Alvord, Familial amyotrophic lateral sclerosis, 1850?1989: a statistical analysis of the world literature. The Canadian journal of neurological sciences Le journal canadien des sciences neurologiques, pp.45-58, 1991.

A. Millul, E. Beghi, G. Logroscino, A. Micheli, E. Vitelli et al., Survival of Patients with Amyotrophic Lateral Sclerosis in a Population-Based Registry, Neuroepidemiology, vol.60, issue.3, pp.114-123, 2005.
DOI : 10.1002/mus.880160107

J. Lee, J. Annegers, and S. Appel, Prognosis of amyotrophic lateral sclerosis and the effect of referral selection, Journal of the Neurological Sciences, vol.132, issue.2, pp.207-222, 1995.
DOI : 10.1016/0022-510X(95)00154-T

E. Sorenson, J. Mandrekar, B. Crum, and J. Stevens, Effect of referral bias on assessing survival in ALS, Neurology, vol.68, issue.8, pp.600-602, 2007.
DOI : 10.1212/01.wnl.0000254501.58158.e7

G. Logroscino, E. Beghi, O. Hardiman, A. Chio, J. Mitchell et al., Effect of referral bias on assessing survival in als):939; author reply -40. https, Neurology, vol.69, issue.9, 2007.

S. Zoccolella, E. Beghi, G. Palagano, A. Fraddosio, V. Guerra et al., ALS multidisciplinary clinic and survival. Results from a population-based study in Southern Italy, Journal of neurology. Epub, vol.25414, issue.8, pp.1107-1119, 2007.
DOI : 10.1007/s00415-006-0401-y

J. Rooney, S. Byrne, M. Heverin, K. Tobin, A. Dick et al., A multidisciplinary clinic approach improves survival in ALS: a comparative study of ALS in Ireland and Northern Ireland, Journal of Neurology, Neurosurgery & Psychiatry, vol.76, issue.5, pp.496-501, 2015.
DOI : 10.1212/WNL.0b013e318214359f

B. Marin, G. Logroscino, F. Boumediene, A. Labrunie, P. Couratier et al., Clinical and demographic factors and outcome of amyotrophic lateral sclerosis in relation to population ancestral origin, European Journal of Epidemiology, vol.74, issue.936, pp.229-274, 2016.
DOI : 10.1136/jnnp.74.9.1258
URL : https://hal.archives-ouvertes.fr/hal-01217277

L. Ng, F. Khan, and S. Mathers, Multidisciplinary care for adults with amyotrophic lateral sclerosis or motor neuron disease, Cochrane Database Syst Rev, issue.4, p.7425, 2009.
DOI : 10.1002/14651858.cd007425.pub2

H. Mitsumoto, B. Brooks, and V. Silani, Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?, The Lancet Neurology, vol.13, issue.11, pp.1127-1165, 2014.
DOI : 10.1016/S1474-4422(14)70129-2

A. Chio, A. Canosa, S. Gallo, S. Cammarosano, C. Moglia et al., ALS clinical trials: Do enrolled patients accurately represent the ALS population?, Neurology, vol.77, issue.15, pp.1432-1439, 2011.
DOI : 10.1212/WNL.0b013e318232ab9b

B. Traynor, M. Codd, B. Corr, C. Forde, E. Frost et al., Clinical Features of Amyotrophic Lateral Sclerosis According to the El Escorial and Airlie House Diagnostic Criteria, Archives of Neurology, vol.57, issue.8, pp.1171-1177, 2000.
DOI : 10.1001/archneur.57.8.1171
URL : http://archneur.jamanetwork.com/data/journals/neur/13139/noc90081.pdf

J. Rooney, C. Brayne, K. Tobin, G. Logroscino, M. Glymour et al., Benefits, pitfalls, and future design of population-based registers in neurodegenerative disease, Neurology, vol.88, issue.24, pp.2321-2330, 2017.
DOI : 10.1212/WNL.0000000000004038

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