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Article Dans Une Revue Anticancer Research Année : 2011

Oncogramme, a new promising method for individualized breast tumour response testing for cancer treatment.

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Résumé

BACKGROUND: Breast cancer is the most widely spread cancer in the world, attracting much research and individualized tumour response testing (ITRT) methods are now used to individualize patient chemotherapeutic administrations. A new ITRT method was developed with optimized processing. MATERIALS AND METHODS: Breast tumour fragments were separated and the cells seeded in a foetal calf serum-free defined medium. After various chemotherapeutic treatments, cytotoxicity was determined by cell death detection with calcein acetoxymethyl and ethidium homodimer labelling. RESULTS: The culture medium allowed breast tumour cell proliferation in culture, while preventing fibroblastic cell survival. Moreover, the cell death analysis gave rise to a chemoresistance profile called an Oncogramme, with statistically significant values. CONCLUSION: The Oncogramme is a new ITRT method which can predict patient cell sensitivities to chemotherapeutics and should be validated by a new phase I clinical trial.
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hal-01820823 , version 1 (22-06-2018)

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  • HAL Id : hal-01820823 , version 1
  • PUBMED : 21273591

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Stéphanie Giraud, E. Loum, Barbara Bessette, V Fermeaux, Christophe Lautrette. Oncogramme, a new promising method for individualized breast tumour response testing for cancer treatment.. Anticancer Research, 2011, 31 (1), pp.139-145. ⟨hal-01820823⟩
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