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Article dans une revue
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas
Abstract : Background
Gliomas are tumors of the central nervous system derived from glial cells. They show cellular heterogeneity and lack specific diagnostic markers. Although a possible role for the eicosanoid cascade has been suggested in glioma tumorigenesis, the relationship between enzymes and receptors implicated in arachidonic acid metabolism, with histological tumor type has not yet been determined.
Design and methods
Quantitative real-time reverse transcription-polymerase chain reaction was performed to measure and compare transcript levels of enzymes and receptors implicated in both lipoxygenase and cyclooxygenase pathways between oligodendrogliomas, astrocytomas, glioblastomas and mixed oligoastrocytomas.
Results
Arachidonic acid metabolism-related enzymes and receptor transcripts (i) were underexpressed in classical oligodendrogliomas compared to astrocytomas and/or glioblastomas, (ii) differed between astrocytomas and glioblastomas and (iii) had an intermediate expression in mixed oligoastrocytomas.
Conclusions
mRNA levels of enzymes and receptors implicated both in lipoxygenase and cyclooxygenase pathways differed significantly in gliomas according to the histological type.
https://hal-unilim.archives-ouvertes.fr/hal-01820947
Contributeur : Philippe Sindou <>
Soumis le : vendredi 22 juin 2018 - 10:45:33
Dernière modification le : vendredi 15 janvier 2021 - 10:02:06
Contributeur : Philippe Sindou <>
Soumis le : vendredi 22 juin 2018 - 10:45:33
Dernière modification le : vendredi 15 janvier 2021 - 10:02:06
