Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease

Pasquale Varriale; Antoine Collomb-Clerc; Angèle van Hamme; Anaik Perrochon; Gilles Kemoun; Giuseppe Sorrentino; Nathalie George; Brian Lau; Carine Karachi; Marie-Laure Welter

doi:10.1016/j.clinph.2018.07.013

Article dans une revue

Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease

Pasquale Varriale ¹ Antoine Collomb-Clerc ^{2, 1} Angèle van Hamme ¹ Anaik Perrochon ³ Gilles Kemoun ³ Giuseppe Sorrentino ⁴ Nathalie George ¹ Brian Lau ¹ Carine Karachi ¹ Marie-Laure Welter ¹

1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

2 Département de Neurologie [CHU Pitié-Salpêtrière]

3 MOVE - Laboratoire "Mobilité, Vieillissement, Exercice" (MOVE)

4 University Parthenope of Naples

Abstract : Freezing of gait (FOG) represents a major burden for Parkinson's disease (PD) patients. High-frequency (130-Hz) subthalamic deep-brain-stimulation (STN-DBS) has been reported to aggravate FOG whereas lowering the frequency to 60-80 Hz improves FOG. To further understand the effects of STN-DBS on FOG, we assessed the effects of 80-Hz and 130-Hz STN-DBS on gait initiation performance, in relation to motor and executive function processing.

Keywords : Deep brain stimulation Gait initiation Cognitive interference Subthalamic nucleus Parkinson’s disease

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Sciences cognitives / Neurosciences

Sciences cognitives / Psychologie

Sciences du Vivant [q-bio] / Neurosciences [q-bio.NC] / Psychologie et comportements

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https://hal-unilim.archives-ouvertes.fr/hal-01887224
Contributeur : Jean-Christophe Daviet <>
Soumis le : mercredi 3 octobre 2018 - 17:54:17
Dernière modification le : vendredi 25 juin 2021 - 03:33:27

Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease

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