Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease

Pasquale Varriale (1) , Antoine Collomb-Clerc (2, 1) , Angèle van Hamme (1) , Anaik Perrochon (3) , Gilles Kemoun (3) , Giuseppe Sorrentino (4) , Nathalie George (1) , Brian Lau (1) , Carine Karachi (1) , Marie-Laure Welter (1)

1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
2 Service de Neurologie [CHU Pitié-Salpêtrière]
3 MOVE - Laboratoire "Mobilité, Vieillissement, Exercice" (MOVE)
4 PARTHENOPE - Università degli Studi di Napoli “Parthenope” = University of Naples

Freezing of gait (FOG) represents a major burden for Parkinson's disease (PD) patients. High-frequency (130-Hz) subthalamic deep-brain-stimulation (STN-DBS) has been reported to aggravate FOG whereas lowering the frequency to 60-80 Hz improves FOG. To further understand the effects of STN-DBS on FOG, we assessed the effects of 80-Hz and 130-Hz STN-DBS on gait initiation performance, in relation to motor and executive function processing.

Mots clés: Parkinson’s disease; Subthalamic nucleus; Gait initiation; Cognitive interference; Deep brain stimulation

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Sciences cognitives; Neurosciences; Sciences cognitives; Psychologie; Sciences du Vivant [q-bio]; Neurosciences [q-bio.NC]; Psychologie et comportements

Pasquale Varriale, Antoine Collomb-Clerc, Angèle van Hamme, Anaik Perrochon, Gilles Kemoun, et al.. Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease. Clinical Neurophysiology, 2018, 129 (11), pp.2482-2491. ⟨10.1016/j.clinph.2018.07.013⟩. ⟨hal-01887224⟩