Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Resting energy expenditure equations in amyotrophic lateral sclerosis, creation of an ALS-specific equation

Abstract : IntroductionResting energy expenditure (REE) formulas for healthy people (HP) are used to calculate REE (cREE) in amyotrophic lateral sclerosis (ALS) patients. In 50–60% of ALS cases an increase of measured REE (mREE) in indirect calometry (IC) compared to cREE is found. The aims here were (i) to assess the accuracy of cREE assessed using 11 formulas as compared to mREE and (ii) to create (if necessary) a specific cREE formula for ALS patients.Method315 Patients followed in the ALS expert center of Limoges between 1996 and 2014 were included. mREE assessed with IC and cREE calculated with 11 predictive formulas (Harris Benedict (HB) 1919, HB 1984, WSchofield, De Lorenzo, Johnstone, Mifflin, WHO/FAO, Owen, Fleisch, Wang and Rosenbaum) were determined at the time of diagnosis. Fat free mass (FFM) and fat mass (FM) were measured with impedancemetry. A Bland and Altman analysis was carried out. The percentage of accurate prediction ±10% of mREE, and intraclass correlation coefficients (ICC) were calculated. Using a derivation sample, a new REE formula was created using multiple linear regression according to sex, age, FFM and FM. Accuracy of this formula was assessed in a validation sample.ResultsICC ranged between 0.60 and 0.71 (moderate agreement), and percentage of accurate prediction between 27.3% and 57.5%. Underestimation was found from 31.7% to 71.4% of cases. According to these unsatisfactory results we created an ALS-specific formula in a derivation sample (130 patients). ICC and percentage of accurate prediction increased in a validation sample (143 patients) to 0.85 (very good agreement) and 65.0% respectively, with 17.5% underestimation.ConclusionREE formulas for HP underestimate REE in ALS patients compared to mREE. Our new ALS-specific formula produced better results than formulas for HP. This formula can be used to estimate REE in ALS patients if IC is not accessible.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Accord Elsevier CCSD Connectez-vous pour contacter le contributeur
Soumis le : lundi 25 octobre 2021 - 10:27:22
Dernière modification le : samedi 26 mars 2022 - 04:25:16
Archivage à long terme le : : mercredi 26 janvier 2022 - 18:56:20


Fichiers produits par l'(les) auteur(s)


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale 4.0 International License




Pierre Jésus, Benoît Marin, Philippe Fayemendy, Marie Nicol, Géraldine Lautrette, et al.. Resting energy expenditure equations in amyotrophic lateral sclerosis, creation of an ALS-specific equation. Clinical Nutrition, 2018, S0261-5614 (18), pp.32385-32389. ⟨10.1016/j.clnu.2018.08.014⟩. ⟨hal-01898596⟩



Consultations de la notice


Téléchargements de fichiers