Tracking Cancer Cells with Microfluidic High Frequency DEP Cytometer Implemented on BiCMOS Lab-on-Chip Platform

Rémi Manczak (1) , Fatima Hjeij (1) , Thomas Provent (1) , Sofiane Saada (2) , Claire Dalmay (1) , Barbara Bessette (2) , Gaëlle Bégaud (2) , Serge Battu (2) , Pierre Blondy (1) , Marie-Odile Jauberteau (2) , Fabrice Lalloué (2) , Mesut Inac (3) , Canan Baristiran Kaynak , Mehmet Kaynak , Cristiano Palego , Arnaud Pothier (1)

1 XLIM - XLIM
2 CAPTuR - Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance thérapeutique
3 IHP - Leibniz-Institut für innovative Mikroelektronik

In this paper, a fully BiCMOS integrated microfluidic cell sorting platform for cell properties study is introduced. Operating in the radiofrequency range, the presented device combined Lab-on-Chip and IC technologies to achieve label free cytometry using in flow cell selective dielectrophoresis deviation. Taking benefit of CMOS stack and integration capability, the first prototypes demonstrate the ability to separate cells with different intracellular dielectric properties. These results pave the way to new innovative high throughput integrated IC solutions for detection of rare cells in the frame of cancer researches and treatment.

Mots clés: High Frequency Dielectrophoresis; Glioblas-toma; BiCMOS Chip; Biological cell manipulation and analysis.

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire

Rémi Manczak, Fatima Hjeij, Thomas Provent, Sofiane Saada, Claire Dalmay, et al.. Tracking Cancer Cells with Microfluidic High Frequency DEP Cytometer Implemented on BiCMOS Lab-on-Chip Platform. IEEE Xplore Digital Library, 2018, ⟨10.1109/MWSYM.2018.8439466⟩. ⟨hal-01975284⟩