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Local carotid arterial stiffness is an independent determinant of left ventricular remodeling in never-treated hypertensive patients

Abstract : PURPOSE: The aim was to investigate the association between blood pressure (BP), carotid stiffness, carotid-femoral pulse wave velocity (cfPWV) and left ventricular (LV) remodeling in never-treated hypertensive patients. MATERIAL AND METHODS: 178 never-treated hypertensive underwent transthoracic echocardiography, 24-hour ambulatory BP monitoring (ABPM), local carotid stiffness and regional cfPWV assessed using a high-definition echo-tracking ultrasound system and a tonometric transducer, respectively. LV parameters and arterial stiffness were also considered in dippers and non-dippers. RESULTS: Mean night-time BP best correlated with carotid and LV parameters. Carotid stiffness parameters (β-index, pressure-strain elastic modulus, one-point PWV) correlated with LV mass, relative wall thickness, and E/A ratio while cfPWV correlated only with E/A ratio. In multiple regression analysis, age and mean night-time ABPM had a stroger relation with carotid stiffness than cfPWV. In a second multiple regression analysis, day and night ABPM and carotid stiffness were independently related with LV remodeling and left atrial volume. In non-dippers, local carotid stiffness parameters were significantly higher than in dippers, whereas cfPWV was not significantly different. CONCLUSIONS: Carotid stiffness parameters are independently associated with LV remodeling and have an additive effect to BP and over cfPWV moreover local arterial stiffness is higher in non-dippers.
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https://hal-unilim.archives-ouvertes.fr/hal-02020881
Contributeur : Elisabeth Grelier <>
Soumis le : vendredi 15 février 2019 - 14:55:20
Dernière modification le : samedi 16 février 2019 - 01:25:01

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  • HAL Id : hal-02020881, version 1

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Olga Vriz, Julien Magne, Joanna Jarosh, Eduardo Bossone, Victor Aboyans, et al.. Local carotid arterial stiffness is an independent determinant of left ventricular remodeling in never-treated hypertensive patients. Blood Pressure, Taylor & Francis, 2019, 28 (1), pp.23-33. ⟨hal-02020881⟩

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