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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2018

Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii

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E. Keats Shwab
  • Fonction : Auteur
Pooja Saraf
  • Fonction : Auteur
Xing-Quan Zhu
  • Fonction : Auteur
Dong-Hui Zhou
  • Fonction : Auteur
Brent Mcferrin
  • Fonction : Auteur
Gereon Schares
  • Fonction : Auteur
Kenneth Hammond-Aryee
  • Fonction : Auteur
Steven Higgins
  • Fonction : Auteur
Richard Gerhold
  • Fonction : Auteur
Benjamin Rosenthal
  • Fonction : Auteur
Chunlei Su
  • Fonction : Auteur

Résumé

A majority of emerging infectious diseases in humans are zoonoses. Understanding factors that influence the emergence and transmission of zoonoses is pivotal for their prevention and control. Toxoplasma gondii is one of the most widespread zoonotic pathogens known today. Whereas only a few genotypes of T. gondii dominate in the Northern Hemisphere, many genotypes coexist in South America. Furthermore, T. gondii strains from South America are more likely to be virulent than those from the Northern Hemisphere. However, it is not clear what factor(s) shaped modern-day genetic diversity and virulence of T. gondii Here, our analysis suggests that the rise and expansion of farming in the past 11,000 years established the domestic cat/mouse transmission cycle for T. gondii, which has undoubtedly played a significant role in the selection of certain linages of T. gondii Our mathematical simulations showed that within the domestic transmission cycle, intermediately mouse-virulent T. gondii genotypes have an adaptive advantage and eventually become dominant due to a balance between lower host mortality and the ability to superinfect mice previously infected with a less virulent T. gondii strain. Our analysis of the global type II lineage of T. gondii suggests its Old World origin but recent expansion in North America, which is likely the consequence of global human migration and trading. These results have significant implications concerning transmission and evolution of zoonotic pathogens in the rapidly expanding anthropized environment demanded by rapid growth of the human population and intensive international trading at present and in the future.
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Dates et versions

hal-02025034 , version 1 (19-02-2019)

Identifiants

  • HAL Id : hal-02025034 , version 1

Citer

E. Keats Shwab, Pooja Saraf, Xing-Quan Zhu, Dong-Hui Zhou, Brent Mcferrin, et al.. Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (29), pp.E6956-E6963. ⟨hal-02025034⟩
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