The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

Ignatios Ikonomidis; Victor Aboyans; Jacque Blacher; Marianne Brodmann; Dirk Brutsaert; Julio Chirinos; Marco de Carlo; Victoria Delgado; Patrizio Lancellotti; John Lekakis; Dania Mohty; Petros Nihoyannopoulos; John Parissis; Damiano Rizzoni; Frank Ruschitzka; Petar Seferovic; Eugenio Stabile; Dimitrios Tousoulis; Dragos Vinereanu; Charalambos Vlachopoulos; Dimitrios Vlastos; Panagiotis Xaplanteris; Reuven Zimlichman; Marco Metra

The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

Ignatios Ikonomidis ^{1, *} Victor Aboyans ^{2, 3} Jacque Blacher Marianne Brodmann ⁴ Dirk Brutsaert Julio Chirinos Marco de Carlo Victoria Delgado ⁵ Patrizio Lancellotti ⁶ John Lekakis Dania Mohty ^{3, 7} Petros Nihoyannopoulos ⁸ John Parissis Damiano Rizzoni Frank Ruschitzka Petar Seferovic Eugenio Stabile Dimitrios Tousoulis Dragos Vinereanu ⁹ Charalambos Vlachopoulos Dimitrios Vlastos Panagiotis Xaplanteris Reuven Zimlichman Marco Metra ¹⁰

* Auteur correspondant

1 2nd Cardiology Department

2 Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges]

3 NET - Neuroépidémiologie Tropicale

4 Department of Internal Medicine

5 Leiden University Medical Center (LUMC)

6 CHU-Liège - Centre Hospitalier Universitaire de Liège

7 Service de cardiologie [CHU Limoges]

8 Cardiology

9 Cardiology

10 Università degli Studi di Brescia [Brescia]

Abstract : Ventricular-arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment possesses independent diagnostic and prognostic value and may be used to refine riskstratification and monitor therapeutic interventions. Traditionally, VAC is assessed by the non-invasive measurement of the ratio of arterial (Ea) to ventricular end-systolic elastance (Ees). With disease progression, both Ea and Ees may become abnormal and the Ea/Ees ratio may approximate its normal values. Therefore, the measurement of each component of this ratio or of novel more sensitive markers of myocardial (e.g. global longitudinal strain) and arterial function (e.g. pulse wave velocity) may better characterize VAC. In valvular heart disease, systemic arterial compliance and valvulo-arterial impedance have an established diagnostic and prognostic value and may monitor the effects of valve replacement on vascular and cardiac function. Treatment guided to improve VAC through improvement of both or each one of its components may delay incidence of heart failure and possibly improve prognosis in heart failure. In this consensus document, we describe the pathophysiology, the methods of assessment as well as the clinical implications of VAC in cardiac diseases and heart failure. Finally, we focus on interventions that may improve VAC and thus modify prognosis.

Keywords : Arterial elastance Coronary artery disease Global longitudinal strain Heart failure Hypertension Inflammatory disease Prognosis Pulse wave velocity Treatment Valvular heart disease Ventricular-arterial coupling Ventricular elastance

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Article dans une revue

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Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-02086291
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 1 avril 2019 - 11:51:08
Dernière modification le : mardi 2 avril 2019 - 02:40:14

Ignatios Ikonomidis, Victor Aboyans, Jacque Blacher, Marianne Brodmann, Dirk Brutsaert, et al.. The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association. European Journal of Heart Failure, Oxford University Press (OUP), 2019, ⟨10.1002/ejhf.1436⟩. ⟨hal-02086291⟩

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