Abstract : Abstract: 1H-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole was synthesized via a multi-step pathway starting from 2-iodoaniline. Structure characterization of this new indole compound was achieved by 1H-NMR, 13C-NMR and ESI-MS spectral analysis. The title compound was screened in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani and Trypanosoma brucei brucei). Biological results showed antiparasitic activity with IC50 values in the μM range.
https://hal-unilim.archives-ouvertes.fr/hal-02149772
Contributeur : Elisabeth Grelier
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Soumis le : jeudi 6 juin 2019 - 16:15:51
Dernière modification le : mercredi 19 février 2020 - 01:02:32
