Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: A case report and review

Juliette Gay (1) , Nicolas Gendron , Charles Verney (2) , Valentin Joste (3) , Marie‐laure Dardé (4, 5) , Charlotte Loheac (2) , François Vrtovsnik (6) , Nicolas Argy (3) , Sandrine Houzé (7)

1 UPD5 Pharmacie - Faculté de Pharmacie de Paris - Université Paris Descartes
2 Service de Néphrologie [Bichat-Claude Bernard]
3 MERIT - UMR_D 216 - Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique
4 NET - Neuroépidémiologie Tropicale
5 Service de Parasitologie Mycologie [CHU Limoges]
6 CIC - CHU Bichat
7 laboratoire parasitologie, CHU Bichat Paris

Disseminated toxoplasmosis is infrequent after kidney transplant transmission but life‐threatening because of a lack of diagnostic suspicion as well as specific chemoprophylaxis recommendations. Solid organ transplantation has resulted in few cases of disseminated toxoplasmosis presenting with associated hemophagocytic syndrome. Herein, we report, within the context of a donor/receiver mismatch, a case of a toxoplasmosis associated with hemophagocytic syndrome in a kidney transplant recipient. Molecular and serological investigations confirmed Toxoplasma gondii transmission through the kidney graft.

Mots clés: Hemophagocytic syndrome; renal transplant; Toxoplasmosis

Domaines: Santé publique et épidémiologie

Juliette Gay, Nicolas Gendron, Charles Verney, Valentin Joste, Marie‐laure Dardé, et al.. Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: A case report and review. Transplant Infectious Disease, 2019, pp.213154. ⟨10.1111/tid.13154⟩. ⟨hal-02274839⟩