New biomarkers for primary mitral regurgitation

Céline Deroyer , Julien Magne (1, 2) , Marie Moonen (3) , Caroline Le Goff (4) , Laura Dupont , Alexia Hulin , Marc Radermecker , Alain Colige (3) , Etienne Cavalier (5) , Philippe Kolh , Luc Pierard (6) , Patrizio Lancellotti (6) , Marie-Paule Merville , Marianne Fillet (3)

1 NET - Neuroépidémiologie Tropicale
2 Service de cardiologie [CHU Limoges]
3 CHU-Liège - Centre Hospitalier Universitaire de Liège
4 Service de chimie clinique
5 University Hospital of Sart-Tilman
6 Service de cardiologie [Liège]

Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease.

Mots clés: Autophagy; Biomarkers; Lipid metabolism; Mitral regurgitation

Domaines: Sciences du Vivant [q-bio]; Santé publique et épidémiologie

Céline Deroyer, Julien Magne, Marie Moonen, Caroline Le Goff, Laura Dupont, et al.. New biomarkers for primary mitral regurgitation. Clinical Proteomics, 2015, 12 (1), pp.25. ⟨10.1186/s12014-015-9097-2⟩. ⟨hal-02318692⟩