Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola

Abstract : Human African Trypanosomiasis may become manageable in the next decade with fexinidazole. However, currently stage diagnosis remains difficult to implement in the field and requires a lumbar puncture. Our study of an Angolan cohort of T. b. gambiense-infected patients used other staging criteria than those recommended by the WHO. We compared WHO criteria (cell count and parasite identification in the CSF) with two biomarkers (neopterin and CXCL-13) which have proven potential to diagnose disease stage or relapse. Biological, clinical, and neurological data were analysed from a cohort of 83 patients. A neopterin concentration below 15.5 nmol/L in the CSF denoted patients with stage 1 disease, and a concentration above 60.31 nmol/L characterized patients with advanced stage 2 (trypanosomes in CSF and/or cytorachia higher than 20 cells) disease. CXCL-13 levels below 91.208 pg/mL denoted patients with stage 1 disease, and levels of CXCL-13 above 395.45 pg/mL denoted patients with advanced stage 2 disease. Values between these cut-offs may represent patients with intermediate stage disease. Our work supports the existence of an intermediate stage in HAT, and CXCL-13 and neopterin levels may help to characterize it.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-02378676
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 25 novembre 2019 - 12:24:11
Dernière modification le : jeudi 28 novembre 2019 - 10:48:13

Lien texte intégral

Identifiants

Collections

Citation

Julien Bonnet, Philippe Vignoles, Natalia Tiberti, Vatunga Gedeão, Alexandre Hainard, et al.. Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola. BioMed Research International , Hindawi Publishing Corporation, 2019, 2019, pp.1-9. ⟨10.1155/2019/6070176⟩. ⟨hal-02378676⟩

Partager

Métriques

Consultations de la notice

57