Increased resting energy expenditure compared with predictive theoretical equations in amyotrophic lateral sclerosis

Pierre Jésus (1, 2) , Philippe Fayemendy (1, 2) , Benoît Marin (3, 2) , Marie Nicol (4, 2) , Huguette Sourisseau (1) , Yves Y. Boirie (5) , Stéphane Walrand (5) , Najate Achamrah (6, 7, 8, 9) , Moïse Coëffier (6, 7, 8, 9) , Pierre-Marie Preux (2, 10, 3) , Géraldine Lautrette (4) , Philippe Couratier (4, 2) , Jean-Claude Desport (2, 1)

1 Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]
2 NET - Neuroépidémiologie Tropicale
3 Laboratoire de Biostatistique et d'Informatique Médicale
4 Service de Neurologie [CHU Limoges]
5 UNH - Unité de Nutrition Humaine
6 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
7 IRIB - Institute for Research and Innovation in Biomedicine
8 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
9 Service de Nutrition [CHU Rouen]
10 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

Approximately 50% to 60% of amyotrophic lateral sclerosis (ALS) is characterized by an increase in metabolic rate. The Harris and Benedict (HB) 1919 formula is the equation mainly used to calculate resting energy expenditure (cREE) compared with measured REE (mREE) by indirect calorimetry (IC), but other formulas are also applied in current practice. The present study aimed to assess mREE in patients with ALS compared with 12 cREE formulas and study the relevant threshold of REE variation to screen patients with a higher evolving risk.

Mots clés: Amyotrophic lateral sclerosis; Evolution; Metabolic rate; Predictive equation; Resting energy expenditure; Survival

Domaines: Santé publique et épidémiologie; Physiologie [q-bio.TO]

Pierre Jésus, Philippe Fayemendy, Benoît Marin, Marie Nicol, Huguette Sourisseau, et al.. Increased resting energy expenditure compared with predictive theoretical equations in amyotrophic lateral sclerosis. Nutrition, 2020, 77, pp.110805. ⟨10.1016/j.nut.2020.110805⟩. ⟨hal-02862745⟩