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Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

Abstract : Twenty four aminoporphyrin derivatives have been tested in vitro for their antibacterial photoactivity against Escherichia coli and Staphylococcus aureus. Two of these compounds, bearing polyamine units, exhibited a significant activity especially against Gram-negative bacteria (E. coli). Twenty four aminoporphyrin derivatives have been tested in vitro for their antibacterial photoactivity against Escherichia coli and Staphylococcus aureus. Two of these compounds, bearing polyamine units (17–18) exhibited a significant activity especially against gram-negative bacteria. For 17, 18: R1=R2=R3=R4=H, a=CH3, b=CHCH2 and c=(CH2)2COspermidine for 17, c=(CH2)2COspermine for 18.
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https://hal-unilim.archives-ouvertes.fr/hal-02895616
Contributeur : Vincent Sol <>
Soumis le : jeudi 9 juillet 2020 - 21:08:35
Dernière modification le : mercredi 7 octobre 2020 - 08:34:03

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Vincent Sol, Pierre Branland, Vincent Chaleix, Robert Granet, Michel Guilloton, et al.. Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2004, 14 (16), pp.4207-4211. ⟨10.1016/j.bmcl.2004.06.016⟩. ⟨hal-02895616⟩

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