Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

Vincent Sol; Pierre Branland; Vincent Chaleix; Robert Granet; Michel Guilloton; François Lamarche; Bernard Verneuil; Pierre Krausz

doi:10.1016/j.bmcl.2004.06.016

Article dans une revue

Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

Vincent Sol ¹ Pierre Branland ¹ Vincent Chaleix ¹ Robert Granet ¹ Michel Guilloton ¹ François Lamarche ¹ Bernard Verneuil ¹ Pierre Krausz ¹

1 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : Twenty four aminoporphyrin derivatives have been tested in vitro for their antibacterial photoactivity against Escherichia coli and Staphylococcus aureus. Two of these compounds, bearing polyamine units, exhibited a significant activity especially against Gram-negative bacteria (E. coli). Twenty four aminoporphyrin derivatives have been tested in vitro for their antibacterial photoactivity against Escherichia coli and Staphylococcus aureus. Two of these compounds, bearing polyamine units (17–18) exhibited a significant activity especially against gram-negative bacteria. For 17, 18: R1=R2=R3=R4=H, a=CH3, b=CHCH2 and c=(CH2)2COspermidine for 17, c=(CH2)2COspermine for 18.

Keywords : Escherichia coli Porphyrin derivatives Polyamines Photodynamic antimicrobial chemotherapy

Type de document :

Article dans une revue

Domaine :

Chimie

Chimie / Chimie organique

Sciences du Vivant [q-bio]

Sciences du Vivant [q-bio] / Microbiologie et Parasitologie

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https://hal-unilim.archives-ouvertes.fr/hal-02895616
Contributeur : Vincent Sol <>
Soumis le : jeudi 9 juillet 2020 - 21:08:35
Dernière modification le : mercredi 7 octobre 2020 - 08:34:03

Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

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