Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

Vincent van Rixel , Vadde Ramu , Austin Auyeung , Nataliia Beztsinna , David Leger (1) , Lucien Lameijer , Stan Hilt , Sylvia Le Dévédec , Tugba Yildiz , Tania Betancourt , M. Brenton Gildner , Todd Hudnall , Vincent Sol (2) , Bertrand Liagre (1) , Alexander Kornienko , Sylvestre Bonnet (3)

1 PEIRENE - PEIRENE
2 LCSN - Laboratoire de Chimie des Substances Naturelles
3 Leiden Institute of Chemistry

Domaines: Chimie; Chimie organique; Sciences du Vivant [q-bio]; Cancer

Vincent van Rixel, Vadde Ramu, Austin Auyeung, Nataliia Beztsinna, David Leger, et al.. Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model. Journal of the American Chemical Society, 2019, 141 (46), pp.18444-18454. ⟨10.1021/jacs.9b07225⟩. ⟨hal-02922070⟩