Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study

Henri Salle 1, 2, * Elise Deluche 3 Elodie Couvé-Deacon 4 Anne-Claire Beaujeux 1 Johan Pallud 5, 6 Alexandre Roux 5, 6 Arnaud Dagain Amaury de Barros 7 Jimmy Voirin 8 Romuald Seizeur 9, 10 Houda Belmabrouk 9 Leslie Lemnos 1 Evelyne Emery 11, 12 Marie-Jeanne Fotso 13 Julien Engelhardt 14 Vincent Jecko 14, 15 Ilyess Zemmoura 16, 17 Tuan Le Van 18 Moncef Berhouma 19, 20 Hélène Cebula 21 Matthieu Peyre 22 Pierre-Marie Preux 23, 24, 25 François Caire 1, 26
* Auteur correspondant
5 Ima-Brain [Paris] - Biomarqueurs en imagerie : neuro développement et pathologies cérébrales
IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
Abstract : Background The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients. Methods Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals. Results We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients. Discussion Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-02966620
Contributeur : Elisabeth Grelier <>
Soumis le : mercredi 14 octobre 2020 - 11:04:20
Dernière modification le : vendredi 16 octobre 2020 - 03:39:58

Lien texte intégral

Identifiants

Citation

Henri Salle, Elise Deluche, Elodie Couvé-Deacon, Anne-Claire Beaujeux, Johan Pallud, et al.. Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study. Infection, Springer Verlag, 2020, ⟨10.1007/s15010-020-01534-0⟩. ⟨hal-02966620⟩

Partager

Métriques

Consultations de la notice

27