Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects

Philippe Fayemendy; Benoit Marin; Anaïs Labrunie; Yves Boirie; Stéphane Walrand; Najate Achamrah; Moïse Coëffier; Pierre-Marie Preux; Géraldine Lautrette; Jean-Claude Desport; Philippe Couratier; Pierre Jésus

doi:10.1016/j.jns.2020.117257

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Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects

Philippe Fayemendy ^{1, 2, *} Benoit Marin ^{1, 3, 4} Anaïs Labrunie ^{3, 1} Yves Boirie ^{5, 6} Stéphane Walrand ⁶ Najate Achamrah ^{7, 8, 9, 10} Moïse Coëffier ^{7, 8, 9, 10} Pierre-Marie Preux ^{1, 11, 4} Géraldine Lautrette ¹² Jean-Claude Desport ^{1, 2} Philippe Couratier ^{1, 12} Pierre Jésus ^{1, 2}

* Auteur correspondant

1 NET - Neuroépidémiologie Tropicale

2 Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges]

3 CEBIMER - Plate forme de bioinformatique et biostatistique

4 Laboratoire de Biostatistique et d'Informatique Médicale

5 CRNH d'Auvergne - Centre de Recherche en Nutrition Humaine d'Auvergne

6 UNH - Unité de Nutrition Humaine

7 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau

8 IRIB - Institute for Research and Innovation in Biomedicine

9 Service de nutrition [CHU Rouen]

10 UNIROUEN UFR Santé - UNIROUEN - UFR Santé

11 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

12 Service de Neurologie [CHU Limoges]

Abstract : Rationale Hypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the reflection of a high energy metabolic level, but this alteration seems controversial. The main objective of the study was to confirm the existence of HM during ALS compared to healthy subjects. Methods A cohort of ALS patients was compared to a control group without metabolic disorder. The assessment included anthropometric criteria measurements, body composition by bioelectric impedance analysis and resting energy expenditure (REE) by indirect calorimetry. HM was defined as a variation > +10% between measured and calculated REE. Statistical analysis used Mann-Withney and Chi2 tests. Multivariate analysis included logistic regression. Results 287 patients and 75 controls were included. The metabolic level was higher in ALS patients (1500 kcal/24 h [1290–1693] vs. 1230 kcal/24 h [1000–1455], p < 0.0001) as well as the REE/fat free mass ratio (33.5 kcal/kg/24 h [30.4–37.8] vs. 28.3 kcal/kg/24 h [26.1–33.6], p < 0.0001). 55.0% of ALS patients had HM vs. 13.3% of controls (p < 0.0001). HM was strongly and positively associated with ALS (OR = 9.50 [4.49–20.10], p < 0.0001). Conclusions HM in ALS is a reality, which affects more than half of the patients and is associated with ALS. This work confirms a very frequent metabolic deterioration during ALS. The identification of HM can allow a better adaptation of the patients' nutritional intake.

Keywords : Resting energy expenditure Hypermetabolism Amyotrophic lateral sclerosis

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-03043219
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 7 décembre 2020 - 11:02:54
Dernière modification le : mercredi 31 mars 2021 - 09:55:11

Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects

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