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Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

Susanne Röhr 1, 2, * Alexander Pabst 1 Steffi Riedel-Heller 1 Frank Jessen 3, 4 Yuda Turana 5 Yvonne Handajani 5 Carol Brayne 6 Fiona Matthews 7, 8 Blossom Stephan 9 Richard Lipton 10 Mindy Katz 10 Cuiling Wang Maëlenn Guerchet 11 Pierre-Marie Preux 11, 12, 13 Pascal Mbelesso 11 Karen Ritchie 14 Marie-Laure Ancelin 14 Isabelle Carrière 14 Antonio Guaita 15 Annalisa Davin 16 Roberta Vaccaro 15 Ki Woong Kim 16 Ji Won Han 16 Seung Wan Suh 16 Suzana Shahar 17 Normah Din 18 Divya Vanoh 19 Martin van Boxtel 20 Sebastian Köhler 20 Mary Ganguli 20 Erin Jacobsen 20 Beth Snitz 20 Kaarin Anstey 21 Nicolas Cherbuin 21 Shuzo Kumagai 21 Sanmei Chen Kenji Narazaki Tze Pin Ng Qi Gao Xinyi Gwee Henry Brodaty Nicole Kochan Julian Trollor Antonio Lobo Raúl López-Antón Javier Santabárbara John Crawford Darren Lipnicki Perminder Sachdev 
Abstract : Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
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Soumis le : lundi 11 janvier 2021 - 12:25:04
Dernière modification le : mercredi 26 octobre 2022 - 04:06:20

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Susanne Röhr, Alexander Pabst, Steffi Riedel-Heller, Frank Jessen, Yuda Turana, et al.. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research and Therapy, 2020, 12 (167), ⟨10.1186/s13195-020-00734-y⟩. ⟨hal-03105760⟩



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