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Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

Susanne Röhr 1, 2, * Alexander Pabst 1 Steffi Riedel-Heller 1 Frank Jessen 3, 4 Yuda Turana 5 Yvonne Handajani 5 Carol Brayne 6 Fiona Matthews 7, 8 Blossom Stephan 9 Richard Lipton 10 Mindy Katz 10 Cuiling Wang Maëlenn Guerchet 11 Pierre-Marie Preux 11, 12, 13 Pascal Mbelesso 11 Karen Ritchie 14 Marie-Laure Ancelin 15 Isabelle Carrière 15 Antonio Guaita 16 Annalisa Davin 17 Roberta Vaccaro 16 Ki Woong Kim 17 Ji Won Han 17 Seung Wan Suh 17 Suzana Shahar 18 Normah Din 19 Divya Vanoh 20 Martin van Boxtel 21 Sebastian Köhler 21 Mary Ganguli 21 Erin Jacobsen 21 Beth Snitz 21 Kaarin Anstey 22 Nicolas Cherbuin 22 Shuzo Kumagai 22 Sanmei Chen Kenji Narazaki Tze Pin Ng Qi Gao Xinyi Gwee Henry Brodaty Nicole Kochan Julian Trollor Antonio Lobo Raúl López-Antón Javier Santabárbara John Crawford Darren Lipnicki Perminder Sachdev
Abstract : Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
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Contributeur : Elisabeth Grelier <>
Soumis le : lundi 11 janvier 2021 - 12:25:04
Dernière modification le : jeudi 27 mai 2021 - 09:06:02

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Susanne Röhr, Alexander Pabst, Steffi Riedel-Heller, Frank Jessen, Yuda Turana, et al.. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research & Therapy, 2020, 12 (167), ⟨10.1186/s13195-020-00734-y⟩. ⟨hal-03105760⟩



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