Incidence, survival and geoepidemiological analysis of meningiomas and glioblastomas in the province of Catania during the 2003–2016 period

Chaima Chebil (1) , Farid Boumediene (1) , Calogero Edoardo Cicero (2) , Cristina Rascunà (2) , Alessia Di Prima (3) , Antonietta Alfia Maria Torrisi (3) , Antonina Torrisi (3) , Salvatore Sciacca (4) , Mario Zappia (2) , Pierre-Marie Preux (1, 5, 6) , Margherita Ferrante (3) , Alessandra Nicoletti

1 NET - Neuroépidémiologie Tropicale
2 Unict - Università degli studi di Catania = University of Catania
3 University Hospital of Catania
4 Mediterranean Institute of Oncology
5 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]
6 Laboratoire de Biostatistique et d'Informatique Médicale

Background: Meningiomas are the most common primary brain tumors, followed by glioblastomas. Nevertheless, no previous studies have been conducted to evaluate the epidemiology of meningiomas and glioblastomas in the southern region of Italy. Thus, the aim of our study was to evaluate incidence, temporal trend and survival rate of meningiomas and glioblastomas in the province of Catania during the study period. Moreover, a geoepidemiological analysis was performed in order to identify possible geographical and temporal clusters. Methods: All subjects with meningiomas and glioblastomas diagnosed from 2003 to 2016 in the province of Catania were collected, using the local cancer registry. Incidence rate (IR) was calculated by gender, age-groups and tumor behavior. Temporal changes in incidence trend were assessed using a Joinpoint regression analysis while survival analysis was performed using Kaplan-Meier method. Cluster analysis was performed using Kulldorff's spatial scan statistic. Results: In the province of Catania, a total of 1488 cases of meningiomas and 443 cases of glioblastomas were identified from 2003 to 2016, with an IR of 9.8/100,000 person-years (95%CI 9.3-10.3) and 2.9/100,000 person-years (95%CI 2.7-3.2), respectively. Meningiomas were more common among women (p-value<0.0001), while glioblastomas among men (p-value<0.0001). IR progressively increased over the ages, reaching a peak in the 75-84 and 65-74 years-old group in, respectively, meningiomas and glioblastomas. Mean survival was higher in subjects diagnosed with meningiomas as compared to those with glioblastomas (10.7 years and 15.8 months, respectively), with age as the strongest risk factor for death. Spatial and space-time cluster of high incidence of meningiomas was detected in a small community on the eastern flank of the Mt. Etna volcano. Conclusions: Epidemiology of meningioma and glioblastoma in the province of Catania is close to that reported worldwide. Spatial and space-time cluster of meningiomas were found in Pedara. Further studies on risks factor are necessary.

Mots clés: Cancer registry; Cluster; Glioblastoma; Incidence; Meningioma

Domaines: Santé publique et épidémiologie

Chaima Chebil, Farid Boumediene, Calogero Edoardo Cicero, Cristina Rascunà, Alessia Di Prima, et al.. Incidence, survival and geoepidemiological analysis of meningiomas and glioblastomas in the province of Catania during the 2003–2016 period. Environmental Research, 2021, 200, pp.111286. ⟨10.1016/j.envres.2021.111286⟩. ⟨hal-03275558⟩