Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study

Jaime Luna; Jeremy Jost; Mouhamadou Diagana; Leila Ait Aissa; Meriem Tazir; Lamia Ali Pacha; Imen Kacem; Riadh Gouider; Franclo Henning; Anna Basse; Ousmane Cisse; Aa Koffi Balogou; Damelan Kombate; Mendinatou Agbetou; Dismand Houinato; Dieu Donné Gnonlonfoun; Athanase Millogo; Thierry Agba; Mouftao Belo; Noudy Sengxeu; Bello Hamidou; Pierre-Marie Preux; Marin Benoit; Philippe Couratier

doi:10.1080/21678421.2021.1961806

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Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study

Jaime Luna ^{1, *} Jeremy Jost ^{1, 2} Mouhamadou Diagana ¹ Leila Ait Aissa ³ Meriem Tazir ³ Lamia Ali Pacha ³ Imen Kacem ⁴ Riadh Gouider ⁴ Franclo Henning ⁵ Anna Basse ⁶ Ousmane Cisse ⁶ Aa Koffi Balogou ⁷ Damelan Kombate ⁸ Mendinatou Agbetou ⁹ Dismand Houinato ^{1, 10} Dieu Donné Gnonlonfoun ^{10, 1} Athanase Millogo ^{1, 11} Thierry Agba ¹² Mouftao Belo ¹² Noudy Sengxeu ¹ Bello Hamidou ¹ Pierre-Marie Preux ^{1, 13, 14} Marin Benoit ¹ Philippe Couratier ^{1, 15, *}

* Auteur correspondant

1 NET - Neuroépidémiologie Tropicale

2 Service de Pharmacie Centrale [CHU Limoges]

3 Service de Neurologie, C.H.U Mustapha Bacha, Place du 1er Mai, 16000 Alger, Algeria

4 Hopital de Razi - Razi Hospital [Tunis]

5 Stellenbosch University

6 CHNU Fann Dakar

7 Service de Neurologie, CHU Campus Université de Lomé

8 Service de Neurologie, CHU Campus Université de Lomé

9 CNHU-HKM - Centre National Hospitalier Universitaire Hubert K. Maga de Cotonou

10 LEMACEN - Laboratory of Chronic and Neurological Diseases Epidemiology

11 UJZK - Université Joseph Ki-Zerbo [Ouagadougou]

12 Université de Lomé [Togo]

13 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

14 Laboratoire de Biostatistique et d'Informatique Médicale

15 Service de Neurologie [CHU Limoges]

Abstract : Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods: A multicenter observational study involving African hospitals was conducted. A standard questionnaire was developed based on the European Federation of the Neurological Societies (EFNS) guidelines. We collected data on multidisciplinary care and availability of medicines. The availability and affordability were evaluated according to the WHO guidelines. Results: Nine hospital centers from eight African countries participated. We observed a low degree of implementation of multidisciplinary care in ALS management. Riluzole was only available in centers from South Africa, Senegal, Tunisia, and Togo. This treatment was unaffordable and the adjusted price was highly variable among countries. The cost of riluzole was partly or fully covered by patients, which implies a substantial economic burden. Conclusion: Our findings strengthen the need to promote multidisciplinary care in the clinical management of ALS in Africa. Disease-modifying medication should be both available and affordable. Local and international collaboration is needed to improve ALS health care access in Africa.

Keywords : Africa Amyotrophic lateral sclerosis affordability availability management riluzole

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-03339802
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Soumis le : jeudi 9 septembre 2021 - 16:35:16
Dernière modification le : mercredi 20 octobre 2021 - 01:31:14

Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study

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