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Liver elastometry and alcohol withdrawal: Median-term follow-up in a psychiatric unit

Abstract : The measurement of liver stiffness (LS) shows promise as a follow-up tool after alcohol withdrawal, but it has mainly been studied in the early phase or in patients with severe liver disease. A 6-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Trial NCT01491347). Clinical and biological data and LS values were collected every 2 months. A total of 129 patients were included in the study; 93 had an LS assessment within the first 7 days, and 37 had all four LS measurements. Only seven (7.5%) patients had an initial LS > 12.1 kPa, the threshold used to define severe fibrosis. Abstinence was not associated with changes in LS at the various median-term follow-up periods. However, LS of abstinent subjects decreased significantly relative to that of non-abstinent subjects between M0 and M2. CAP™ values were not associated with abstinence. The systematic median-term follow-up of withdrawn patients does not appear to be contributory. However, LS could help to detect relapse in the first 2 months after withdrawal for subjects treated in a psychiatric hospital for dependence. It thus could serve as a motivation tool. Prospective studies with various and higher baseline LS values are warranted for simultaneous longitudinal assessment, including for very short- and long-term LS after withdrawal.
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https://hal-unilim.archives-ouvertes.fr/hal-03434259
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Soumis le : jeudi 18 novembre 2021 - 10:59:30
Dernière modification le : lundi 22 novembre 2021 - 14:49:15

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Paul Carrier, Murielle Girard, Marilyne Debette-Gratien, Natacha Ouedraogo, Véronique Loustaud-Ratti, et al.. Liver elastometry and alcohol withdrawal: Median-term follow-up in a psychiatric unit. Alcohol, Elsevier Masson, 2020, 89, pp.49-56. ⟨10.1016/j.alcohol.2020.07.007⟩. ⟨hal-03434259⟩

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