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Negative symptoms in schizophrenia: correlation with clinical and genetic factors

Abstract : Aim: Explore the possible association between clinical factors and genetic variants of the dopamine pathways and negative symptoms. Materials & methods: Negative symptoms were assessed in 206 patients with schizophrenia using the Arabic version of the self-evaluation of negative symptoms scale and the Positive and Negative Syndrome Scale. Genotyping for COMT, DRD2, MTHFR and OPRM1 genes was performed. Results: Multivariable analysis showed that higher self-evaluation of negative symptoms scale scores were significantly associated with higher age, higher chlorpromazine-equivalent daily dose for typical antipsychotics and in married patients. Higher negative Positive and Negative Syndrome Scale scores were significantly associated with women and having the CT genotype for MTHFR c.677C>T (β = 4.25; p = 0.008) compared with CC patients. Conclusion: Understanding both clinical/genetic factors could help improve the treatment of patients.
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https://hal-unilim.archives-ouvertes.fr/hal-03575422
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Soumis le : mardi 15 février 2022 - 15:04:49
Dernière modification le : samedi 26 mars 2022 - 04:23:50

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Aline Hajj, Souheil Hallit, Karam Chamoun, Hala Sacre, Sahar Obeid, et al.. Negative symptoms in schizophrenia: correlation with clinical and genetic factors. Pharmacogenomics, Future Medicine, 2021, 22 (7), pp.389-399. ⟨10.2217/pgs-2020-0171⟩. ⟨hal-03575422⟩

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