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Association of insomnia with mania in Lebanese patients with bipolar disorder

Abstract : Objective: To assess: (1) the association between insomnia experienced at admission, sociodemographic and other patients' characteristics and mania; and (2) the variation of insomnia and mania before and after treatment in bipolar patients with manic episodes (type I). Methods: Sixty-two patients were interviewed shortly after their admission to the hospital (after 3 to 5 days). The current symptoms experienced by the patients were assessed upon admission and again at discharge from the hospital. Results: A poorer quality of sleep (higher PSQI scores) (Beta=0.590) was significantly associated with higher mania, whereas the intake of SSRIs (Beta=-5.952) and TCAs (Beta=-8.181) was significantly associated with lower mania. Furthermore, highly significant reductions were reported in the PSQI scores (4.96 vs. 2.75, P<0.001), ISI scores (8.30 vs. 3.45, P<0.001) and YMRS scores (8.60 vs. 3.06, P<0.001) between admission to and discharge from the hospital. Conclusion: Insomnia in patients with bipolar disorder type I is associated with mania, with a significant reduction of sleep problems seen during a period of approximately 20 days of hospitalization. Further longitudinal studies are needed to confirm the validity of our results and identify the causes. In the meantime, this research recommends a strategy to improve sleeplessness experienced during inter-episode phases may be helpful in preventing manic episodes in BD.
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Contributeur : Elisabeth Grelier Connectez-vous pour contacter le contributeur
Soumis le : lundi 21 février 2022 - 15:02:52
Dernière modification le : lundi 25 juillet 2022 - 10:16:23




Chadia Haddad, Sahar Obeid, Lina Ghanem, François Kazour, Aik Yong Chok, et al.. Association of insomnia with mania in Lebanese patients with bipolar disorder. L'Encéphale, Elsevier Masson, 2021, 47 (4), pp.314-318. ⟨10.1016/j.encep.2020.09.008⟩. ⟨hal-03582915⟩



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