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Article Dans Une Revue L'Encéphale Année : 2021

Association of insomnia with mania in Lebanese patients with bipolar disorder

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Résumé

Objective: To assess: (1) the association between insomnia experienced at admission, sociodemographic and other patients' characteristics and mania; and (2) the variation of insomnia and mania before and after treatment in bipolar patients with manic episodes (type I). Methods: Sixty-two patients were interviewed shortly after their admission to the hospital (after 3 to 5 days). The current symptoms experienced by the patients were assessed upon admission and again at discharge from the hospital. Results: A poorer quality of sleep (higher PSQI scores) (Beta=0.590) was significantly associated with higher mania, whereas the intake of SSRIs (Beta=-5.952) and TCAs (Beta=-8.181) was significantly associated with lower mania. Furthermore, highly significant reductions were reported in the PSQI scores (4.96 vs. 2.75, P<0.001), ISI scores (8.30 vs. 3.45, P<0.001) and YMRS scores (8.60 vs. 3.06, P<0.001) between admission to and discharge from the hospital. Conclusion: Insomnia in patients with bipolar disorder type I is associated with mania, with a significant reduction of sleep problems seen during a period of approximately 20 days of hospitalization. Further longitudinal studies are needed to confirm the validity of our results and identify the causes. In the meantime, this research recommends a strategy to improve sleeplessness experienced during inter-episode phases may be helpful in preventing manic episodes in BD.
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Dates et versions

hal-03582915 , version 1 (21-02-2022)

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Chadia Haddad, Sahar Obeid, Lina Ghanem, François Kazour, Aik Yong Chok, et al.. Association of insomnia with mania in Lebanese patients with bipolar disorder. L'Encéphale, 2021, 47 (4), pp.314-318. ⟨10.1016/j.encep.2020.09.008⟩. ⟨hal-03582915⟩
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